Compare Zanaflex vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zanaflex
(Tizanidine)

Neurontin
(Gabapentin)

Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
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Have you used Zanaflex (Tizanidine)?
Worth itNot sureNot worth it
Reviews for Neurontin (Gabapentin)
57%
24% vs. Zanaflex (Tizanidine)
40%
33% vs. Zanaflex (Tizanidine)
19%
Same vs. Zanaflex (Tizanidine)
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Side effects
ZanaflexNeurontin

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
  • Dizziness 9%
  • Hostility 5%
  • Drowsiness 4%
  • Mood swings 3%
  • Weight increase 3%
  • Bronchitis 3%
  • Dry mouth 2%
  • Fatigue 2%
  • Abnormal increase in muscle activity 2%
  • Respiratory infection 2%
More Neurontin side effects »
How it works
ZanaflexNeurontin
Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
ZanaflexNeurontin
Muscle relaxer
Centrally-acting alpha agonist
Prescription only
Anticonvulsant
GABA analog
Prescription only
Available as
ZanaflexNeurontin
  • Pill
  • Pill
  • Oral solution
Used for (click to learn more)
ZanaflexNeurontin
Risk factors for serious side effects
ZanaflexNeurontin
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
Detailed risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ZanaflexNeurontin
  • Don't drink alcohol while using this.
No alcohol related info.
Food
ZanaflexNeurontin
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Need to be consistent every day in taking this with or without food.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Take the extended-release tablet with food.
Pain
ZanaflexNeurontin
No pain related info.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
Sleep
ZanaflexNeurontin
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
Upsides and benefits
ZanaflexNeurontin
  • Relieves muscle spasms well.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides and risks
ZanaflexNeurontin
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
  • Can't stop taking this abruptly if you use it regularly.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
Tips from our pharmacists for people taking the medication
ZanaflexNeurontin
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
Learn more
More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zanaflex (Tizanidine)?
Worth itNot sureNot worth it
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it