Compare Zanaflex vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zanaflex (tizanidine)

Prescription only

Valium (diazepam)

Prescription only
Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

4.3/ 5 average rating with 26 reviewsforZanaflex
Helps you relax.

Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm. Compared to similar drugs, Valium (diazepam) acts very quickly but can have interactions with other medicines.

3.8/ 5 average rating with 976 reviewsforValium
Upsides
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Valium (diazepam) effectively relieves anxiety and muscle spasms.
  • Valium (diazepam) has less severe withdrawal symptoms compared to other similar drugs.
  • Works very quickly.
  • Available in generic.
Downsides
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
  • Use of Valium (diazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Valium (diazepam) can be habit-forming, so it's not typically used for long-term treatment.
  • Most people find that their body will get used to Valium (diazepam) levels and they may need higher doses over time to achieve the same effect.
  • People with severe liver problems should not take Valium (diazepam). Several drugs can also interfere with how Valium (diazepam) works.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
26 reviews so far
81%
saidit'sworth it
73%
saiditworked well
19%
saidit'sa big hassle

Have you used Zanaflex (tizanidine)?

Leave a review
976 reviews so far
70%
saidit'sworth it
53%
saiditworked well
15%
saidit'sa big hassle

Have you used Valium (diazepam)?

Leave a review
Side effects
17possible side effects
  • Dry mouth
    49%
  • Sleepiness
    48%
  • Weakness
    41%
  • Dizziness
    16%
  • Urinary tract infection
    10%
  • General infection
    6%
  • Liver test abnormality
    6%
  • Constipation
    4%
  • Vomiting
    3%
  • Speech disorder
    3%
  • Blurred vision
    3%
  • Urinary frequency
    3%
  • Flu syndrome
    3%
  • Involuntary muscle movement
    3%
  • Nervousness
    3%
  • Sore throat
    3%
  • Hay fever
    3%
See more detailed side effects
The Valium (diazepam) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver damage
    • Taking maximum doses of Zanaflex (tizanidine)
  • Dizziness and low blood pressure
    • Age 65 years or older
    • Currently on blood pressure control medications
  • Sleepiness and driving impairment
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
  • Withdrawal side effects
    • Stopping Zanaflex (tizanidine) suddenly
See more detailed risks and warnings
  • Decreased breathing from use with opioids
    • Taking Valium (diazepam) with opioids, drugs or alcohol
    • Using Valium (diazepam) for a longer duration and at high doses
  • Dependence and withdrawal
    • History of substance abuse
    • Taking with alcohol or drugs
    • Taking long-term
    • Taking a higher dose
    • Stopping Valium (diazepam) suddenly
  • Driving impairment
    • Alcohol use with Valium (diazepam)
    • Taking other medicines that make you less alert
  • Drug interactions
    • Current liver problems
    • Taking Tagamet, ketoconazole, Prozac, Prilosec
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.