Compare Zantac vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75
(ranitidine)

Rolaids
(Calcium Carbonate / Magnesium Hydroxide)

Relieves heartburn and stomach ulcers. Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.08Zantac
Reviews for Zantac
72%
of people (All ages) say Zantac is worth it
44%
say it works well
7%
say it's a big hassle
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Reviews for Rolaids
75%
-3% worse vs. Zantac
37%
+7% better vs. Zantac
7%
Same vs. Zantac
1089 reviews
Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?
Worth itNot sureNot worth it
Side effects
ZantacRolaids

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
How it works
ZantacRolaids
Zantac 75 (ranitidine) reduces the production of acid by blocking a chemical from acting on the acid-producing cells in your stomach.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
ZantacRolaids
Prescription or OTCLower-cost generic availableOver-the-counterLower-cost generic available
Available as
ZantacRolaids
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Chewable tablet
  • Liquid
Used for
ZantacRolaids
Risk factors for serious side effects
ZantacRolaids
  • Aged 60 years or older
  • Kidney conditions
  • Liver conditions
  • Acute Porphyria
  • Asthma
Detailed Zantac 75 (ranitidine) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Hyperparathyroid disease
  • Taking high doses of Vitamin D
  • Previous kidney stones
Detailed Rolaids (Calcium Carbonate / Magnesium Hydroxide) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
ZantacRolaids
  • Zantac 75 (ranitidine) can interact with certain prescription and over-the-counter medications. Let your doctor or pharmacist know about the medicines you are currently taking.
No interactions related info.
Alcohol
ZantacRolaids
  • The syrup product may contain up to 7.5% of alcohol.
No alcohol related info.
Kidneys and liver
ZantacRolaids
No kidneys and liver related info.
  • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
  • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
Upsides and benefits
ZantacRolaids
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides and risks
ZantacRolaids
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
Tips from our pharmacists for people taking the medication
ZantacRolaids
  • To prevent a heartburn attack, take Zantac 75 (ranitidine) 30 minutes before eating.
  • Works within 30 to 60 minutes. Relief lasts up to 12 hours.
  • Do not use Zantac 75 (ranitidine) for more than 14 days. Talk to your doctor if your symptoms do not improve after 2 weeks of using the over-the-counter product, as this may indicate a more serious problem.
  • The syrup product may contain up to 7.5% of alcohol.
  • Speak to your doctor or pharmacist about lifestyle and dietary changes that can help prevent heartburn.
  • Take at the first sign of discomfort.
  • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
  • Take 1-2 hours apart from other medication that you take by mouth.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • Don't take if you have high blood calcium levels.
Learn more
More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?
Worth itNot sureNot worth it