Compare Zantac vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75
(Ranitidine)

Rolaids
(Calcium Carbonate / Magnesium Hydroxide)

Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.068636796949476Zantac
Reviews for Zantac 75 (Ranitidine)
72%
of people say Zantac 75 (Ranitidine) is worth it
43%
say it works well
7%
say it's a big hassle
Reviews for Rolaids (Calcium Carbonate / Magnesium Hydroxide)
75%
+3% vs. Zantac 75 (Ranitidine)
37%
6% vs. Zantac 75 (Ranitidine)
7%
Same vs. Zantac 75 (Ranitidine)
Side effects
ZantacRolaids

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
How it works
ZantacRolaids
Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
ZantacRolaids
Acid reducer
Histamine blocker
Prescription or OTC
AntacidOver-the-counter
Available as
ZantacRolaids
  • Pill
  • Oral solution
  • Injection
  • Chewable tablet
  • Liquid
Used for (click to learn more)
ZantacRolaids
Risk factors for serious side effects
ZantacRolaids
    • Current kidney problems
    • Current liver problems
    • Acute Porphyria
    • History of Phenylketonuria (PKU)
    Detailed Zantac 75 (Ranitidine) risks & warnings »
      • Current kidney disease
      • Kidney dialysis
      • Hyperparathyroid disease
      • Taking high doses of Vitamin D
      • Previous kidney stones
      Detailed Rolaids (Calcium Carbonate / Magnesium Hydroxide) risks & warnings »
      Pregnancy category
      ZantacRolaids
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • People with kidney disease may need to take a lower dose.
      • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
      • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      ZantacRolaids
      • Most people can take Ranitidine without any noticeable day-to-day side effects.
      • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
      • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
      • Available as both a generic and over-the-counter option, so it's pretty affordable.
      • Few drug interactions.
      • Works really fast.
      • Available over the counter without a prescription.
      • Cheap.
      Downsides and risks
      ZantacRolaids
      • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
      • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
      • Doesn't last very long.
      • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
      • Some chalky aftertaste.
      Tips from our pharmacists for people taking the medication
      ZantacRolaids
      • Works best if you take it with a full glass of water.
      • Starts working in one hour.
      • People with kidney disease may need to take a lower dose.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • Take at the first sign of discomfort.
      • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
      • Take 1-2 hours apart from other medication that you take by mouth.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • Don't take if you have high blood calcium levels.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      Learn more
      More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
      More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert