Compare Zantac vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75 (ranitidine)

Prescription or OTC

Tagamet (cimetidine)

Prescription or OTC
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

3.7/ 5 average rating with 1062 reviewsforZantac
Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

3.4/ 5 average rating with 632 reviewsforTagamet
Upsides
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Pill
  • Liquid
Price
No pricing information available
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Reviews
1062 reviews so far
72%
saidit'sworth it
44%
saiditworked well
7%
saidit'sa big hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
632 reviews so far
63%
saidit'sworth it
36%
saiditworked well
12%
saidit'sa big hassle

Have you used Tagamet (cimetidine)?

Leave a review
Side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Confusion
    • Aged 60 years or older
    • Kidney conditions
    • Liver conditions
  • Drug interactions
  • Acute porphyria
    • Acute Porphyria
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
See more detailed risks and warnings
  • Confusion
    • Elderly
    • Kidney problems
    • Liver problems
    • Dementia
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Clostridium difficile associated diarrhea
    • Taking antibiotics
  • Englarged breasts in men (gynecomastia)
See more detailed risks and warnings