Compare Zantac vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75
(ranitidine)

Tums
(calcium carbonate)

Relieves heartburn and stomach ulcers. Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.Relieves heartburn. Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.08Zantac
Reviews for Zantac
72%
of people (All ages) say Zantac is worth it
44%
say it works well
7%
say it's a big hassle
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Reviews for Tums
82%
-10% worse vs. Zantac
43%
+1% better vs. Zantac
5%
-2% worse vs. Zantac
1373 reviews
Have you used Tums (calcium carbonate)?
Worth itNot sureNot worth it
Side effects
ZantacTums

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »

We haven’t found good data for Tums side effects.

FDA side effect reports for Tums »
How it works
ZantacTums
Zantac 75 (ranitidine) reduces the production of acid by blocking a chemical from acting on the acid-producing cells in your stomach.Tums (Calcium carbonate) is an antacid. It relieves heartburn and indigestion by neutralizing stomach acid.
Type of medication
ZantacTums
Prescription or OTCOver-the-counter
Available as
ZantacTums
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Chewable tablet
  • Liquid
Used for
ZantacTums
Risk factors for serious side effects
ZantacTums
  • Aged 60 years or older
  • Kidney conditions
  • Liver conditions
  • Acute Porphyria
  • Asthma
Detailed Zantac 75 (ranitidine) risks & warnings »
    Coming soon.
    Pregnancy
    Interactions
    ZantacTums
    • Zantac 75 (ranitidine) can interact with certain prescription and over-the-counter medications. Let your doctor or pharmacist know about the medicines you are currently taking.
    No interactions related info.
    Alcohol
    ZantacTums
    • The syrup product may contain up to 7.5% of alcohol.
    No alcohol related info.
    Kidneys and liver
    ZantacTums
    No kidneys and liver related info.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    Upsides and benefits
    ZantacTums
    • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • If you have trouble swallowing pills you may find the liquid product a good option.
    • Inexpensive with over-the-counter and generic options.
    • Coupons are available for the brand product - speak to your doctor or pharmacist.
    • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
    • Tums (Calcium carbonate) starts working in seconds.
    • Has minimal side effects.
    • Available in chewable form.
    • Is inexpensive and readily available over-the-counter.
    • Coupons are available – speak to your doctor or pharmacist.
    Downsides and risks
    ZantacTums
    • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
    • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
    • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
    • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
    • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    • May have a chalky taste.
    Tips from our pharmacists for people taking the medication
    ZantacTums
    • To prevent a heartburn attack, take Zantac 75 (ranitidine) 30 minutes before eating.
    • Works within 30 to 60 minutes. Relief lasts up to 12 hours.
    • Do not use Zantac 75 (ranitidine) for more than 14 days. Talk to your doctor if your symptoms do not improve after 2 weeks of using the over-the-counter product, as this may indicate a more serious problem.
    • The syrup product may contain up to 7.5% of alcohol.
    • Speak to your doctor or pharmacist about lifestyle and dietary changes that can help prevent heartburn.
    • Take at the first sign of discomfort.
    • You may need to separate Tums (Calcium carbonate) from some medicines to avoid interactions. Talk to your doctor or pharmacist about all the medicines you're taking, including prescription, supplements, and over the counter medicines.
    • Eating smaller, more frequent meals can help alleviate some symptoms of heartburn.
    • Certain spicy or fatty foods increase your risk of heartburn. Talk to your doctor or pharmacist to find out which foods you should avoid.
    • Avoiding eating 3 hours before bedtime can also help prevent heartburn.
    • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
    Learn more
    More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zantac 75 (ranitidine)?
    Worth itNot sureNot worth it
    More about TumsSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tums (calcium carbonate)?
    Worth itNot sureNot worth it