Compare Zantac vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75
(ranitidine)

Tums
(calcium carbonate)

Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn. Tums (Calcium Carbonate) gives quick relief for heartburn, but don't expect it to last all day.
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Prices and coupon for 60 (150mg) tablets of ranitidine
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Prices and coupon for 60 (500mg) tablets of calcium carbonate
Reviews & ratings
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5.08Zantac
Reviews for Zantac 75 (ranitidine)
72%
of people (All ages) say Zantac 75 (ranitidine) is worth it
44%
say it works well
7%
say it's a big hassle
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Reviews for Tums (calcium carbonate)
82%
+10% better vs. Zantac 75 (ranitidine)
43%
-1% worse vs. Zantac 75 (ranitidine)
5%
+2% better vs. Zantac 75 (ranitidine)
1373 reviews
Have you used Tums (calcium carbonate)?
Worth itNot sureNot worth it
Side effects
ZantacTums

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »

We haven’t found good data for Tums side effects.

FDA side effect reports for Tums »
How it works
ZantacTums
Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Tums (Calcium Carbonate) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
ZantacTums
Prescription or OTC
Over-the-counter
Available as
ZantacTums
  • Pill
  • Oral solution
  • Injection
  • Chewable tablet
  • Liquid
Used for
ZantacTums
Risk factors for serious side effects
ZantacTums
    • Current kidney problems
    • Current liver problems
    • Acute Porphyria
    • History of Phenylketonuria (PKU)
    Detailed Zantac 75 (ranitidine) risks & warnings »
      • Current kidney disease
      • Kidney dialysis
      • Hyperparathyroid disease
      • Taking high doses of Vitamin D
      • Previous kidney stones
      Detailed Tums (calcium carbonate) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Interactions
      ZantacTums
      • Few drug interactions.
      • You need to separate Tums from some medications to avoid interactions.
      Kidneys and liver
      ZantacTums
      • People with kidney disease may need to take a lower dose.
      • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • If you have kidney or hyperparathyroid disease Tums (Calcium Carbonate) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Tums (Calcium Carbonate); a different antacid would be better for you.
      • Tums (Calcium Carbonate) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Tums (Calcium Carbonate). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
      Upsides and benefits
      ZantacTums
      • Most people can take Ranitidine without any noticeable day-to-day side effects.
      • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
      • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
      • Available as both a generic and over-the-counter option, so it's pretty affordable.
      • Few drug interactions.
      • Works really fast.
      • Available over the counter without a prescription.
      • Cheap.
      Downsides and risks
      ZantacTums
      • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
      • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
      • Doesn't last very long.
      • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
      • Some chalky aftertaste.
      Tips from our pharmacists for people taking the medication
      ZantacTums
      • Works best if you take it with a full glass of water.
      • Starts working in one hour.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • People with kidney disease may need to take a lower dose.
      • Take at the first sign of discomfort.
      • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
      • You need to separate Tums from some medications to avoid interactions.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • Don't take if you have high blood calcium levels.
      Learn more
      More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zantac 75 (ranitidine)?
      Worth itNot sureNot worth it
      More about TumsSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Tums (calcium carbonate)?
      Worth itNot sureNot worth it