Compare Zantac vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75 (ranitidine)

Prescription or OTC

Tums (Calcium carbonate)

Over-the-counter
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

5.1/ 7 average rating with 1062 reviewsforZantac
Relieves heartburn.

Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.

5.2/ 7 average rating with 1373 reviewsforTums
Upsides
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
  • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
  • Tums (Calcium carbonate) starts working in seconds.
  • Has minimal side effects.
  • Available in chewable form.
  • Is inexpensive and readily available over-the-counter.
  • Coupons are available – speak to your doctor or pharmacist.
Downsides
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
  • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
  • May increase calcium levels too much in people with kidney or thyroid conditions.
  • May have a chalky taste.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Chewable tablet
  • Liquid
No pricing information available
No pricing information available
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Reviews
1062 
72%
think this treatment is worth it
44%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
1373 
82%
think this treatment is worth it
43%
think this treatment works well
5%
think this treatment is a hassle

Have you used Tums (Calcium carbonate)?

Leave a review
Side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
The Tums (Calcium carbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Confusion

    Aged 60 years or older

    ...and 2 more risk factors

  • Acute porphyria

    Acute Porphyria

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings
No information currently available