Compare Zegerid vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Omeprazole / Sodium Bicarbonate)

Alka-Seltzer Original
(Aspirin / Citric Acid / Sodium Bicarbonate)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn, headache, and body pains. Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
say it works well
say it's a big hassle
Reviews for Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)
+10% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
2% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
+5% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
1053 reviews
Side effects

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Alka-Seltzer side effects.

FDA side effect reports for Alka-Seltzer »
How it works
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) is a combination medicine. Sodium bicarbonate is an antacid that relieves heartburn and acid tummy (indigestion). Aspirin is a pain reliever that treats headache and body pains.
Type of medication
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
  • Pill
  • Chewable tablet
  • Effervescent tablet
Used for (click to learn more)
Risk factors for serious side effects
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Current kidney disease
          • Kidney dialysis
          • Age 65 or older
          • Congestive heart failure (CHF)
          • High blood pressure
          • Current kidney disease
          • Kidney dialysis
          • Children 18 years or younger recovering from viral infections
          • History of stomach bleeding or ulcers
          • Age 60 or older
          • Also taking other blood thinners
          • Drinking 3 or more alcoholic drinks a day
          • Asthma
          • Rhinitis
          • Nasal Polyps
          • Aspirin Allergy
          • NSAID Allergy
            Detailed Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) risks & warnings »
            Pregnancy category
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            NFDA pregnancy category (Unknown)

            The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

            See the FDA package insert
            No specific alcohol-related info.No specific alcohol-related info.
            • Take 1 hour before a meal.
            • Take it with food to lower the chance of an upset stomach.
            Kidneys and liver
            No specific kidneys and liver-related info.
            • If you have kidney or hyperparathyroid disease Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) can build up in your blood. This may can cause toxic levels of sodium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate); a different antacid would be better for you.
            • Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) contains sodium. Sodium can raise blood pressure and cause your body to hold on to water. If you have high blood pressure, heart failure, or kidney disease you should not take Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate).
            No specific sex-related info.No specific sex-related info.
            No specific sleep-related info.No specific sleep-related info.
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            • Most people can take Zegerid without any noticeable day-to-day side effects.
            • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Works great if you have an upset stomach and a headache or body pain at the same time.
            • Works really fast.
            • Available over the counter without a prescription.
            • Cheap.
            Downsides and risks
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
            • Although the generic is affordable, other medications might still be cheaper than Zegerid.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
            • Doesn't last very long.
            • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
            • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
            • Can't be used by people with allergy to aspirin.
            • You may not like the taste or fizz.
            Tips from our pharmacists for people taking the medication
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
            • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
            • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
            • Don't take Alka-Seltzer if you're allergic to aspirin.
            • Take it with food to lower the chance of an upset stomach.
            • This medicine isn't recommended for kids 12 and younger because it has aspirin in it.
            • Stop taking this right away and talk to your doctor if you have ringing in your ears, rash, trouble breathing, unusual bleeding, or nausea or vomiting that doesn't go away.
            • Having a dental or medical procedure? You may need to stop taking this before the big day. Ask your dentist or doctor.
            • Alka-Seltzer contains sodium. If you need to follow a low sodium diet a different medication would be better for you.
            • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, or gout, or if you're taking medicines to thin your blood.
            Learn more
            More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
            More about Alka-SeltzerSide effectsReviews & ratingsAlternativesFDA package insert