Compare Zegerid vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Omeprazole / Sodium Bicarbonate)

(Aluminum / Magnesium / Simethicone)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.
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Reviews & ratings
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Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
of people (All ages) say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
say it works well
say it's a big hassle
Have you used Zegerid (Omeprazole / Sodium Bicarbonate)?
Worth itNot sureNot worth it
Reviews for Maalox (Aluminum / Magnesium / Simethicone)
3% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
24% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
+4% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
212 reviews
Have you used Maalox (Aluminum / Magnesium / Simethicone)?
Worth itNot sureNot worth it
Side effects

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »
How it works
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.
Type of medication
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
Risk factors for serious side effects
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
        • Age 65 or older
          • Current kidney disease
            Detailed Maalox (Aluminum / Magnesium / Simethicone) risks & warnings »
            Pregnancy category
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            NFDA pregnancy category (Unknown)

            The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

            See the FDA package insert
            • Take 1 hour before a meal.
            • Take 1-3 hours after a meal.
            Kidneys and liver
            No specific kidneys and liver related info.
            • People with kidney disease may need to avoid Maalox. Ask your doctor.
            • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
            Upsides and benefits
            • Most people can take Zegerid without any noticeable day-to-day side effects.
            • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Works really fast.
            • Available over the counter without a prescription.
            • Cheap.
            Downsides and risks
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
            • Although the generic is affordable, other medications might still be cheaper than Zegerid.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
            • Doesn't last very long.
            • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
            • Some people don't care for the taste.
            Tips from our pharmacists for people taking the medication
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
            • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
            • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
            • Take 1-3 hours after a meal.
            • Take 1-2 hours apart from other medication that you take by mouth.
            • Tell your doctor if you have severe diarrhea or constipation.
            • People with kidney disease may need to avoid Maalox. Ask your doctor.
            Learn more
            More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Zegerid (Omeprazole / Sodium Bicarbonate)?
            Worth itNot sureNot worth it
            More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Maalox (Aluminum / Magnesium / Simethicone)?
            Worth itNot sureNot worth it