Compare Zegerid vs. Nexium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(Omeprazole / Sodium Bicarbonate)

Nexium
(Esomeprazole)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Nexium (Esomeprazole) gives you long-lasting heartburn relief. But this purple pill ain't cheap! The generic forms of alternative drugs work just as well, and are usually less expensive.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.185714285714286Zegerid
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
71%
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
54%
say it works well
13%
say it's a big hassle
Reviews for Nexium (Esomeprazole)
75%
+4% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
59%
+5% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
11%
+2% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
Side effects
ZegeridNexium

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

The Nexium FDA package insert doesn’t have numbers about how common side effects are.

More about Nexium side effects »
How it works
ZegeridNexium
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Nexium (Esomeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
ZegeridNexium
Acid reducer
Proton pump inhibitor
Antacid
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
ZegeridNexium
  • Pill
  • Extended release
Used for (click to learn more)
ZegeridNexium
Risk factors for serious side effects
ZegeridNexium
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Helicobacter pylori infection
          • Autoimmune disease
          • Being hospitalized
          • Antibiotic use
          • Osteoporosis
          • Age 50 or older
          • Using high medication doses
          • Long-term therapy (1 year or more)
          • Smoking
          • Use of other medications that weaken bones
            Detailed Nexium (Esomeprazole) risks & warnings »
            Pregnancy category
            ZegeridNexium
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take 1 hour before a meal.
            • Take 1 hour before a meal.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            ZegeridNexium
            • Most people can take Zegerid without any noticeable day-to-day side effects.
            • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Nexium without any noticeable day-to-day side effects.
            • Nexium lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            ZegeridNexium
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
            • Although the generic is affordable, other medications might still be cheaper than Zegerid.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Nexium long-term.
            • Can be expensive—especially the purple brand-name pill. Other alternatives are usually cheaper than Nexium and work just as well.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            Tips from our pharmacists for people taking the medication
            ZegeridNexium
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
            • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
            • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
            • When using Nexium long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Nexium.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            Learn more
            More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
            More about NexiumSide effectsReviews & ratingsAlternativesFDA package insert