Compare Zegerid vs. Pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(Omeprazole / Sodium Bicarbonate)

Protonix
(Pantoprazole)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.185714285714286Zegerid
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
71%
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
54%
say it works well
13%
say it's a big hassle
Reviews for Protonix (Pantoprazole)
69%
2% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
51%
3% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
13%
Same vs. Zegerid (Omeprazole / Sodium Bicarbonate)
Side effects
ZegeridPantoprazole

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
How it works
ZegeridPantoprazole
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
ZegeridPantoprazole
Acid reducer
Proton pump inhibitor
Antacid
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription only
Available as
ZegeridPantoprazole
  • Pill
  • Extended release
Used for (click to learn more)
ZegeridPantoprazole
Risk factors for serious side effects
ZegeridPantoprazole
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Helicobacter pylori infection
          • Autoimmune disease
          • Osteoporosis
          • Age 50 or older
          • Using high medication doses
          • Long-term therapy (1 year or more)
          • Smoking
          • Use of other medications that weaken bones
              Detailed Protonix (Pantoprazole) risks & warnings »
              Pregnancy category
              ZegeridPantoprazole
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Take 1 hour before a meal.
              • Take with or without food.
              • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              ZegeridPantoprazole
              • Most people can take Zegerid without any noticeable day-to-day side effects.
              • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
              • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
              • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
              • Available as both a generic and over-the-counter option, so it's pretty affordable.
              • Most people can take Pantoprazole without any noticeable day-to-day side effects.
              • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
              • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
              • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
              • Available as both a generic and over-the-counter option, so it's pretty affordable.
              Downsides and risks
              ZegeridPantoprazole
              • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
              • Although the generic is affordable, other medications might still be cheaper than Zegerid.
              • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
              • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
              • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
              • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
              • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
              • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
              • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
              • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
              Tips from our pharmacists for people taking the medication
              ZegeridPantoprazole
              • Take 1 hour before a meal.
              • Don't chew or crush capsules; swallow them whole.
              • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
              • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
              • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
              • Take with or without food.
              • Swallow tablets whole; don't split, crush, or chew.
              • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
              • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
              • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
              • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
              Learn more
              More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
              More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert