Compare Zegerid vs. pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid (omeprazole and sodium bicarbonate)

Protonix (pantoprazole)

Prescription only
Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

5.2/ 7 average rating with 74 reviewsforZegerid
Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

5.1/ 7 average rating with 584 reviewsforpantoprazole
Upsides
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
Downsides
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
Used for
Dosage forms
  • Pill
  • Suspension
  • Pill
  • Packet
Price
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$3103.61
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$9.35
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Reviews
74 
72%
think this treatment is worth it
55%
think this treatment works well
12%
think this treatment is a hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
584 
68%
think this treatment is worth it
51%
think this treatment works well
13%
think this treatment is a hassle

Have you used Protonix (pantoprazole)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
8possible side effects
  • Headache
    12%
  • Diarrhea
    9%
  • Nausea
    7%
  • Stomach pain
    6%
  • Vomiting
    4%
  • Gas
    4%
  • Dizziness
    3%
  • Joint pain
    3%
See more detailed side effects
Risks and warnings
  • Severe diarrhea

    Elderly

    ...and 1 more risk factors

  • Bone fractures

    Long-term use of Zegerid (omeprazole and sodium bicarbonate)

    ...and 1 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings
  • Weakened bones

    Using multiple daily doses and/or for 1 year or longer

    ...and 2 more risk factors

  • Severe diarrhea

    People who are being treated in the hospital

  • Lupus

    People with lupus

  • Low Vitamin B-12 level

    Taking Protonix (pantoprazole) for more than 3 years

  • Low magnesium level

    Diuretics (water pills)

    ...and 1 more risk factors

See more detailed risks and warnings