Compare Zegerid vs. pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(omeprazole / sodium bicarbonate)

Protonix
(pantoprazole)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.
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Prices and coupon for 30 (40mg/1100mg) capsules of omeprazole / sodium bicarbonate
Coupons for
Prices and coupon for 30 (40mg) tablets of pantoprazole
Reviews & ratings
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5.24Zegerid
Reviews for Zegerid (omeprazole / sodium bicarbonate)
72%
of people (All ages) say Zegerid (omeprazole / sodium bicarbonate) is worth it
55%
say it works well
12%
say it's a big hassle
Have you used Zegerid (omeprazole / sodium bicarbonate)?
Worth itNot sureNot worth it
Reviews for Protonix (pantoprazole)
68%
-4% worse vs. Zegerid (omeprazole / sodium bicarbonate)
51%
-4% worse vs. Zegerid (omeprazole / sodium bicarbonate)
13%
-1% worse vs. Zegerid (omeprazole / sodium bicarbonate)
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Side effects
Zegeridpantoprazole

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
How it works
Zegeridpantoprazole
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.
Type of medication
Zegeridpantoprazole
Prescription or OTC
Prescription only
Available as
Zegeridpantoprazole
  • Pill
  • Pill
  • Packet
Used for
Zegeridpantoprazole
Risk factors for serious side effects
Zegeridpantoprazole
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (omeprazole / sodium bicarbonate) risks & warnings »
        • Using multiple daily doses and/or for 1 year or longer
        • People age 65 or older
        • High risk of bone fractures
        • People who are being treated in the hospital
          • People with lupus
          • Taking Protonix (pantoprazole) for more than 3 years
          • Diuretics (water pills)
          • Digoxin
          Detailed Protonix (pantoprazole) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          Zegeridpantoprazole
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
          No interactions related info.
          Food
          Zegeridpantoprazole
          • Take 1 hour before a meal.
          • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
          Kidneys and liver
          Zegeridpantoprazole
          No kidneys and liver related info.
          • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
          Pain
          Zegeridpantoprazole
          No pain related info.
          • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
          Upsides and benefits
          Zegeridpantoprazole
          • Most people can take Zegerid without any noticeable day-to-day side effects.
          • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
          • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
          • Can be used in children age 5 or older.
          Downsides and risks
          Zegeridpantoprazole
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
          • Although the generic is affordable, other medications might still be cheaper than Zegerid.
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Needs to be taken every single day for a certain period of time to be effective.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Only available as a prescription medicine, not over the counter.
          • Can lower the magnesium level in your body so you may need to take a supplement for it.
          Tips from our pharmacists for people taking the medication
          Zegeridpantoprazole
          • Take 1 hour before a meal.
          • Don't chew or crush capsules; swallow them whole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
          • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
          • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
          • Take the tablet form of Protonix (pantoprazole) with or without food.
          • The medicine should be swallowed whole and not to to be chewed or crushed.
          • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
          • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
          • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
          • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
          Learn more
          More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Zegerid (omeprazole / sodium bicarbonate)?
          Worth itNot sureNot worth it
          More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Protonix (pantoprazole)?
          Worth itNot sureNot worth it