Compare Zegerid vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(omeprazole / sodium bicarbonate)

Pepcid
(famotidine)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Zegerid
Best available price for 30 (40mg/1100mg) capsules of zegerid
Coupons for Pepcid
Best available price for 60 (20mg) tablets of famotidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.24Zegerid
Reviews for Zegerid
72%
of people (All ages) say Zegerid is worth it
55%
say it works well
12%
say it's a big hassle
Have you used Zegerid (omeprazole / sodium bicarbonate)?
Worth itNot sureNot worth it
Reviews for Pepcid
75%
-3% worse vs. Zegerid
41%
+14% better vs. Zegerid
8%
-4% worse vs. Zegerid
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Side effects
ZegeridPepcid

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
How it works
ZegeridPepcid
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
ZegeridPepcid
Prescription or OTCPrescription or OTC
Available as
ZegeridPepcid
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Used for
ZegeridPepcid
Risk factors for serious side effects
ZegeridPepcid
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Zegerid (omeprazole / sodium bicarbonate) risks & warnings »
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
ZegeridPepcid
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Few drug interactions.
Food
ZegeridPepcid
  • Take 1 hour before a meal.
No food related info.
Kidneys and liver
ZegeridPepcid
No kidneys and liver related info.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Upsides and benefits
ZegeridPepcid
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
ZegeridPepcid
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
  • Although the generic is affordable, other medications might still be cheaper than Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Tips from our pharmacists for people taking the medication
ZegeridPepcid
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
  • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
  • Short-term treatment of ulcers and acid reflux.
Learn more
More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zegerid (omeprazole / sodium bicarbonate)?
Worth itNot sureNot worth it
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it