Compare Zegerid vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(Omeprazole / Sodium Bicarbonate)

Pepcid
(Famotidine)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.185714285714286Zegerid
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
71%
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
54%
say it works well
13%
say it's a big hassle
Reviews for Pepcid (Famotidine)
75%
+4% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
41%
13% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
8%
+5% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
Side effects
ZegeridPepcid

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
How it works
ZegeridPepcid
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
ZegeridPepcid
Acid reducer
Proton pump inhibitor
Antacid
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
ZegeridPepcid
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
ZegeridPepcid
Risk factors for serious side effects
ZegeridPepcid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Current kidney disease
            Detailed Pepcid (Famotidine) risks & warnings »
            Pregnancy category
            ZegeridPepcid
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take 1 hour before a meal.
            No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            ZegeridPepcid
            • Most people can take Zegerid without any noticeable day-to-day side effects.
            • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Famotidine without any noticeable day-to-day side effects.
            • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
            • Few drug interactions.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            ZegeridPepcid
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
            • Although the generic is affordable, other medications might still be cheaper than Zegerid.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
            • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
            • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            Tips from our pharmacists for people taking the medication
            ZegeridPepcid
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
            • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
            • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
            • Short-term treatment of ulcers and acid reflux.
            Learn more
            More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
            More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert