Compare Zegerid vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid (omeprazole and sodium bicarbonate)

Pepcid (Famotidine)

Prescription or OTC
Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

5.2/ 7 average rating with 74 reviewsforZegerid
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

5.1/ 7 average rating with 853 reviewsforPepcid
Upsides
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Used for
Dosage forms
  • Pill
  • Suspension
  • Pill
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$3103.61
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Lowest price near you
$4
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Reviews
74 
72%
think this treatment is worth it
55%
think this treatment works well
12%
think this treatment is a hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
853 
75%
think this treatment is worth it
41%
think this treatment works well
8%
think this treatment is a hassle

Have you used Pepcid (Famotidine)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
Risks and warnings
  • Severe diarrhea

    Elderly

    ...and 1 more risk factors

  • Bone fractures

    Long-term use of Zegerid (omeprazole and sodium bicarbonate)

    ...and 1 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings
  • Increased side effects

    Current kidney disease

See more detailed risks and warnings