Compare Zegerid vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Omeprazole / Sodium Bicarbonate)

(Calcium Carbonate / Magnesium Hydroxide)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
How it works
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
say it works well
say it's a big hassle
Reviews for Rolaids (Calcium Carbonate / Magnesium Hydroxide)
+4% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
17% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
+6% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
Side effects

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
Risk factors for serious side effects
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Current kidney disease
          • Kidney dialysis
          • Hyperparathyroid disease
          • Taking high doses of Vitamin D
          • Previous kidney stones
          Detailed Rolaids (Calcium Carbonate / Magnesium Hydroxide) risks & warnings »
          Pregnancy category
          No specific alcohol-related info.No specific alcohol-related info.
          • Take 1 hour before a meal.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
          • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
          • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          • Most people can take Zegerid without any noticeable day-to-day side effects.
          • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Works really fast.
          • Available over the counter without a prescription.
          • Cheap.
          Downsides and risks
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
          • Although the generic is affordable, other medications might still be cheaper than Zegerid.
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
          • Doesn't last very long.
          • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
          • Some chalky aftertaste.
          Tips from our pharmacists for people taking the medication
          • Take 1 hour before a meal.
          • Don't chew or crush capsules; swallow them whole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
          • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
          • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
          • Take at the first sign of discomfort.
          • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
          • Take 1-2 hours apart from other medication that you take by mouth.
          • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
          • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
          • Don't take if you have high blood calcium levels.
          Learn more
          More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
          More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert