Compare Zegerid vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(Omeprazole / Sodium Bicarbonate)

Rolaids
(Calcium Carbonate / Magnesium Hydroxide)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.24Zegerid
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
72%
of people (All ages) say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
55%
say it works well
12%
say it's a big hassle
Have you used Zegerid (Omeprazole / Sodium Bicarbonate)?
Worth itNot sureNot worth it
Reviews for Rolaids (Calcium Carbonate / Magnesium Hydroxide)
75%
+3% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
37%
18% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
7%
+5% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
1089 reviews
Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?
Worth itNot sureNot worth it
Side effects
ZegeridRolaids

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
How it works
ZegeridRolaids
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
ZegeridRolaids
Acid reducer
Proton pump inhibitor
Antacid
Prescription or OTC
AntacidOver-the-counter
Available as
ZegeridRolaids
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
ZegeridRolaids
Risk factors for serious side effects
ZegeridRolaids
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Hyperparathyroid disease
  • Taking high doses of Vitamin D
  • Previous kidney stones
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
ZegeridRolaids
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
No interactions related info.
Food
ZegeridRolaids
  • Take 1 hour before a meal.
No food related info.
Kidneys and liver
ZegeridRolaids
No kidneys and liver related info.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
  • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
Upsides and benefits
ZegeridRolaids
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides and risks
ZegeridRolaids
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
  • Although the generic is affordable, other medications might still be cheaper than Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
Tips from our pharmacists for people taking the medication
ZegeridRolaids
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
  • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
  • Take at the first sign of discomfort.
  • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
  • Take 1-2 hours apart from other medication that you take by mouth.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • Don't take if you have high blood calcium levels.
Learn more
More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zegerid (Omeprazole / Sodium Bicarbonate)?
Worth itNot sureNot worth it
More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?
Worth itNot sureNot worth it