Compare Zegerid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid (omeprazole and sodium bicarbonate)

Zantac 75 (ranitidine)

Prescription or OTC
Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

5.2/ 7 average rating with 74 reviewsforZegerid
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

5.1/ 7 average rating with 1062 reviewsforZantac
Upsides
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Used for
Dosage forms
  • Pill
  • Suspension
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Price
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$3103.61
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Reviews
74 
72%
think this treatment is worth it
55%
think this treatment works well
12%
think this treatment is a hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
1062 
72%
think this treatment is worth it
44%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe diarrhea

    Elderly

    ...and 1 more risk factors

  • Bone fractures

    Long-term use of Zegerid (omeprazole and sodium bicarbonate)

    ...and 1 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings
  • Confusion

    Aged 60 years or older

    ...and 2 more risk factors

  • Acute porphyria

    Acute Porphyria

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings