Compare Zegerid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zegerid
(Omeprazole / Sodium Bicarbonate)

Zantac 75
(Ranitidine)

Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.185714285714286Zegerid
Reviews for Zegerid (Omeprazole / Sodium Bicarbonate)
71%
of people say Zegerid (Omeprazole / Sodium Bicarbonate) is worth it
54%
say it works well
13%
say it's a big hassle
Reviews for Zantac 75 (Ranitidine)
72%
+1% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
43%
11% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
7%
+6% vs. Zegerid (Omeprazole / Sodium Bicarbonate)
Side effects
ZegeridZantac

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
ZegeridZantac
Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
ZegeridZantac
Acid reducer
Proton pump inhibitor
Antacid
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
ZegeridZantac
  • Pill
  • Pill
  • Oral solution
  • Injection
Used for (click to learn more)
ZegeridZantac
Risk factors for serious side effects
ZegeridZantac
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      • Stroke
      • Coronary artery stent
      • Taking Clopidogrel
      • Rheumatoid arthritis
      • Psoriasis
      • Cancer
      • Taking methotrexate
        Detailed Zegerid (Omeprazole / Sodium Bicarbonate) risks & warnings »
          • Current kidney problems
          • Current liver problems
          • Acute Porphyria
          • History of Phenylketonuria (PKU)
          Detailed Zantac 75 (Ranitidine) risks & warnings »
          Pregnancy category
          ZegeridZantac
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take 1 hour before a meal.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • People with kidney disease may need to take a lower dose.
          • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          ZegeridZantac
          • Most people can take Zegerid without any noticeable day-to-day side effects.
          • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Ranitidine without any noticeable day-to-day side effects.
          • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • Few drug interactions.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          Downsides and risks
          ZegeridZantac
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
          • Although the generic is affordable, other medications might still be cheaper than Zegerid.
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
          Tips from our pharmacists for people taking the medication
          ZegeridZantac
          • Take 1 hour before a meal.
          • Don't chew or crush capsules; swallow them whole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
          • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
          • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
          • Works best if you take it with a full glass of water.
          • Starts working in one hour.
          • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
          • People with kidney disease may need to take a lower dose.
          Learn more
          More about ZegeridSide effectsReviews & ratingsAlternativesFDA package insert
          More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert