Compare Zestoretic vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Catapres
(Clonidine)

Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63265306122449Zestoretic
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
of people (All ages) say Zestoretic (Lisinopril / Hydrochlorothiazide) is worth it
40%
say it works well
17%
say it's a big hassle
294 reviews
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
Reviews for Catapres (Clonidine)
42%
9% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
33%
7% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
34%
17% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
Have you used Catapres (Clonidine)?
Worth itNot sureNot worth it
Side effects
ZestoreticCatapres
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »
How it works
ZestoreticCatapres
Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.
Type of medication
ZestoreticCatapres
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Antihypertensive
Alpha agonist
Prescription only
Available as
ZestoreticCatapres
  • Pill
  • Pill
  • Extended release
  • Patch
Used for (click to learn more)
ZestoreticCatapres
Risk factors for serious side effects
ZestoreticCatapres
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
    Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
    • Sudden discontinuation of medicine
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 years or older
    • Using other medicine(s) that slows the heart
    Detailed Catapres (Clonidine) risks & warnings »
    Pregnancy category
    ZestoreticCatapres
    Kidneys and liver
    • Doesn't work as well in people with severe kidney problems.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
    • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
    No specific kidneys and liver related info.
    Sleep
    No specific sleep related info.
    • Can cause drowsiness, headache, dizziness, and dry mouth.
    Upsides and benefits
    ZestoreticCatapres
    • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
    • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Available in a weekly patch for people that aren't good at taking medicine by mouth.
    • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
    • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
    Downsides and risks
    ZestoreticCatapres
    • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Makes you urinate more often.
    • Doesn't work as well in people with severe kidney problems.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
    • The pill form can make some people sleepy, dizzy, and have dry mouth.
    • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    ZestoreticCatapres
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Usually taken together with other medicines for better blood pressure control.
    • Can cause drowsiness, headache, dizziness, and dry mouth.
    • If side effects don't go away, talk to your doctor about alternatives.
    • The weekly patch form can have fewer side effects.
    • Don't stop taking this medicine suddenly.
    • Extended release tablet also used to treat ADHD.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
    Worth itNot sureNot worth it
    More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Catapres (Clonidine)?
    Worth itNot sureNot worth it