Compare Zestoretic vs. Coreg

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Coreg
(Carvedilol)

Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and controls heart rate. Coreg (Carvedilol) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.63265306122449Zestoretic
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
of people say Zestoretic (Lisinopril / Hydrochlorothiazide) is worth it
40%
say it works well
17%
say it's a big hassle
Reviews for Coreg (Carvedilol)
54%
+3% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
46%
+6% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
18%
1% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
Side effects
ZestoreticCoreg
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »
  • Dizziness 13%
  • Abnormally slow heartbeat 7%
  • Low blood pressure 6%
  • Diarrhea 6%
  • High blood sugar 4%
  • Nausea 4%
  • Vision abnormal 3%
  • Fainting 3%
  • Muscle weakness 2%
  • Edema dependent 2%
More Coreg side effects »
How it works
ZestoreticCoreg
Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.Coreg (Carvedilol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
ZestoreticCoreg
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
ZestoreticCoreg
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
ZestoreticCoreg
Risk factors for serious side effects
ZestoreticCoreg
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
    Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
    • Abrupt discontinuation of Coreg (Carvedilol)
        • Congestive heart failure
        • Increasing the dose of Coreg (Carvedilol)
        • Diabetes
        • Major surgery requiring anesthesia
          Detailed Coreg (Carvedilol) risks & warnings »
          Pregnancy category
          ZestoreticCoreg
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • You have to take Carvedilol with food.
          • Take it with food.
          Kidneys and liver
          • Doesn't work as well in people with severe kidney problems.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Requires routine blood tests to check kidney function.
          • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
          • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
          No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.
          • You may notice worsening symptoms of heart failure if your prescriber decides to increase your dosage of Coreg (Carvedilol). Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as they may make changes to your medications for heart failure.
          Upsides and benefits
          ZestoreticCoreg
          • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
          • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure and heart attack.
          • For people with severe heart failure, Carvedilol lowers the risk of worsening heart failure, hospitalization, and sudden death.
          Downsides and risks
          ZestoreticCoreg
          • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
          • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
          • Makes you urinate more often.
          • Doesn't work as well in people with severe kidney problems.
          • Requires a yearly blood test to see how the medicine is affecting your body.
          • Not safe to use if you're pregnant.
          • You have to take Carvedilol with food.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • You can't miss doses. Stopping Carvedilol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          Tips from our pharmacists for people taking the medication
          ZestoreticCoreg
          • Makes you urinate more often, so avoid taking it at bedtime.
          • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Don't take it if you're pregnant.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Take it with food.
          • Can cause fatigue and erectile dysfunction.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          Learn more
          More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
          More about CoregSide effectsReviews & ratingsAlternativesFDA package insert