Compare Zestoretic vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestoretic
(lisinopril / hydrochlorothiazide)

Microzide
(hydrochlorothiazide )

Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
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4.63Zestoretic
Reviews for Zestoretic (lisinopril / hydrochlorothiazide)
51%
of people (All ages) say Zestoretic (lisinopril / hydrochlorothiazide) is worth it
40%
say it works well
17%
say it's a big hassle
294 reviews
Have you used Zestoretic (lisinopril / hydrochlorothiazide)?
Worth itNot sureNot worth it
Reviews for Microzide (hydrochlorothiazide )
47%
-4% worse vs. Zestoretic (lisinopril / hydrochlorothiazide)
31%
-9% worse vs. Zestoretic (lisinopril / hydrochlorothiazide)
16%
+1% better vs. Zestoretic (lisinopril / hydrochlorothiazide)
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Zestoretichydrochlorothiazide
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Diarrhea 1%
  • Upper respiratory infection 2%
  • Muscle cramps 2%
  • Muscle weakness 1%
More Zestoretic side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Zestoretichydrochlorothiazide
Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Zestoretichydrochlorothiazide
Prescription only
Prescription only
Available as
Zestoretichydrochlorothiazide
  • Pill
  • Pill
Used for
Zestoretichydrochlorothiazide
Risk factors for serious side effects
Zestoretichydrochlorothiazide
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
    Detailed Zestoretic (lisinopril / hydrochlorothiazide) risks & warnings »
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
    • History of sulfa or penicillin allergies
    • Diabetes
    Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Kidneys and liver
    Zestoretichydrochlorothiazide
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
    • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
    • Requires routine blood tests to check kidney function.
    Upsides and benefits
    Zestoretichydrochlorothiazide
    • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
    • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    Downsides and risks
    Zestoretichydrochlorothiazide
    • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Makes you urinate more often.
    • Doesn't work as well in people with severe kidney problems.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    Tips from our pharmacists for people taking the medication
    Zestoretichydrochlorothiazide
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zestoretic (lisinopril / hydrochlorothiazide)?
    Worth itNot sureNot worth it
    More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it