Compare Zestoretic vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.63265306122449Zestoretic
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
of people say Zestoretic (Lisinopril / Hydrochlorothiazide) is worth it
40%
say it works well
17%
say it's a big hassle
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
4% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
31%
9% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
15%
+2% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
Side effects
ZestoreticHydrochlorothiazide
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
ZestoreticHydrochlorothiazide
Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
ZestoreticHydrochlorothiazide
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
ZestoreticHydrochlorothiazide
  • Pill
  • Pill
Used for (click to learn more)
ZestoreticHydrochlorothiazide
Risk factors for serious side effects
ZestoreticHydrochlorothiazide
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
    Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
      Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
      Pregnancy category
      ZestoreticHydrochlorothiazide
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Doesn't work as well in people with severe kidney problems.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
      • Doesn't work well in people with severe kidney problems.
      • Requires routine blood tests to check kidney function.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      ZestoreticHydrochlorothiazide
      • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
      • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Lowers the risk of heart attack and stroke.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      Downsides and risks
      ZestoreticHydrochlorothiazide
      • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Doesn't work as well in people with severe kidney problems.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      • Makes you urinate more often.
      Tips from our pharmacists for people taking the medication
      ZestoreticHydrochlorothiazide
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Don't take it if you're pregnant.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Requires routine blood tests to check kidney function.
      • Starts working in about 2 hours.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Requires routine blood tests to check kidney function.
      Learn more
      More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert