Compare Zestoretic vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood pressure.

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

3.4/ 5 average rating with 294 reviewsforZestoretic
Lowers blood pressure and makes it easier to urinate.

Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.

3.0/ 5 average rating with 48 reviewsforPrazosin
Upsides
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Used for
Dosage forms
  • Pill
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
294 reviews so far
51%
saidit'sworth it
40%
saiditworked well
17%
saidit'sa big hassle

Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?

Leave a review
48 reviews so far
46%
saidit'sworth it
29%
saiditworked well
15%
saidit'sa big hassle

Have you used Minipress (Prazosin)?

Leave a review
Side effects
11possible side effects
  • Dizziness
    8%
  • Headache
    5%
  • Cough
    4%
  • Fatigue
    4%
  • Orthostatic Effects
    3%
  • Diarrhea
    3%
  • Nausea
    2%
  • Upper Respiratory Infection
    2%
  • Muscle Cramps
    2%
  • Asthenia
    2%
  • Paresthesia
    2%
See more detailed side effects
7possible side effects
  • Dizziness
    10%
  • Headache
    8%
  • Drowsiness
    8%
  • Lack of energy
    7%
  • Weakness
    7%
  • Palpitations
    5%
  • Nausea
    5%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Unusual tongue swelling
    • African descent
  • Severe allergic reactions while on dialysis
    • People requiring high flux dialysis
  • Acute kidney failure
    • History of kidney disease
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
  • Cough
See more detailed risks and warnings
  • Low blood pressure (orthostatic hypotension)
    • Age 65 years or older
See more detailed risks and warnings