Compare Zestoretic vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Minipress
(Prazosin)

Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Reviews & ratings
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4.63Zestoretic
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
of people (All ages) say Zestoretic (Lisinopril / Hydrochlorothiazide) is worth it
40%
say it works well
17%
say it's a big hassle
294 reviews
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
Reviews for Minipress (Prazosin)
46%
5% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
29%
11% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
15%
+2% vs. Zestoretic (Lisinopril / Hydrochlorothiazide)
Have you used Minipress (Prazosin)?
Worth itNot sureNot worth it
Side effects
ZestoreticPrazosin
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »

The Prazosin FDA package insert doesn’t have numbers about how common side effects are.

More about Prazosin side effects »
How it works
ZestoreticPrazosin
Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
ZestoreticPrazosin
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Antihypertensive
Alpha blocker
Prescription only
Available as
ZestoreticPrazosin
  • Pill
  • Pill
Used for (click to learn more)
ZestoreticPrazosin
Risk factors for serious side effects
ZestoreticPrazosin
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
Detailed risks & warnings »
  • Age 65 years or older
Detailed risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZestoreticPrazosin
No food related info.
  • Take with food or at bedtime to avoid side effects.
Kidneys and liver
ZestoreticPrazosin
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
No kidneys and liver related info.
Sleep
ZestoreticPrazosin
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and nausea.
Upsides and benefits
ZestoreticPrazosin
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides and risks
ZestoreticPrazosin
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Tips from our pharmacists for people taking the medication
ZestoreticPrazosin
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause drowsiness, headache, dizziness, and nausea.
  • Take with food or at bedtime to avoid side effects.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Recheck your blood pressure 1 week after starting this medicine.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
Learn more
More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minipress (Prazosin)?
Worth itNot sureNot worth it