Compare Zetia vs. Crestor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(Ezetimibe)

Crestor
(Rosuvastatin)

Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Zetia
Reviews for Zetia (Ezetimibe)
42%
of people (All ages) say Zetia (Ezetimibe) is worth it
34%
say it works well
21%
say it's a big hassle
128 reviews
Have you used Zetia (Ezetimibe)?
Worth itNot sureNot worth it
Reviews for Crestor (Rosuvastatin)
60%
+18% vs. Zetia (Ezetimibe)
47%
+13% vs. Zetia (Ezetimibe)
15%
+6% vs. Zetia (Ezetimibe)
751 reviews
Have you used Crestor (Rosuvastatin)?
Worth itNot sureNot worth it
Side effects
ZetiaCrestor

The Zetia FDA package insert doesn’t have numbers about how common side effects are.

More about Zetia side effects »
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
How it works
ZetiaCrestor
Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
ZetiaCrestor
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Cholesterol-lowering
Statin
Prescription only
Available as
ZetiaCrestor
  • Pill
  • Pill
Used for (click to learn more)
ZetiaCrestor
Risk factors for serious side effects
ZetiaCrestor
  • Taking Zetia (Ezetimibe) with statins
  • Past history of liver disease
Detailed risks & warnings »
  • Heavy alcohol use
  • Prior history of chronic liver disease
  • Pregnancy
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
ZetiaCrestor
No alcohol related info.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
ZetiaCrestor
  • Reports of liver disease have been reported in people who take Zetia (Ezetimibe), especially if taken with statins. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
  • Liver damage has been reported in people who take Crestor (Rosuvastatin). If you notice dark urine or yellowing of the eyes or skin, talk to your doctor. Your doctor may monitor your liver periodically.
Upsides and benefits
ZetiaCrestor
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
  • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
Downsides and risks
ZetiaCrestor
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, Zetia is not as effective as statins for improving cholesterol.
  • There's no generic available, so it can be expensive.
  • Even with a generic available in 2016, can be expensive.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
ZetiaCrestor
  • Lowers bad cholesterol, and raises good cholesterol.
  • Tell your doctor if you develop bone or muscle pain.
  • Can be used with other medications to lower cholesterol.
  • May cause diarrhea or raise your chance of getting colds.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Don't take antacids for at least 2 hours before and after taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
Learn more
More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zetia (Ezetimibe)?
Worth itNot sureNot worth it
More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Crestor (Rosuvastatin)?
Worth itNot sureNot worth it