Compare Zetia vs. Lovastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(Ezetimibe)

Mevacor
(Lovastatin)

Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.Lowers cholesterol. Mevacor (Lovastatin) can improve cholesterol, but it's not as strong as other statin medicines. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Zetia
Reviews for Zetia (Ezetimibe)
42%
of people (All ages) say Zetia (Ezetimibe) is worth it
34%
say it works well
21%
say it's a big hassle
128 reviews
Have you used Zetia (Ezetimibe)?
Worth itNot sureNot worth it
Reviews for Mevacor (Lovastatin)
43%
+1% better vs. Zetia (Ezetimibe)
39%
+5% better vs. Zetia (Ezetimibe)
22%
-1% worse vs. Zetia (Ezetimibe)
Have you used Mevacor (Lovastatin)?
Worth itNot sureNot worth it
Side effects
ZetiaLovastatin
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
  • Diarrhea 1%
  • Muscle pain 1%
  • Muscle weakness 1%
  • Elevations of ck levels 11%
More Lovastatin side effects »
How it works
ZetiaLovastatin
Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.Mevacor (Lovastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
ZetiaLovastatin
Prescription only
Prescription only
Available as
ZetiaLovastatin
  • Pill
  • Pill
  • Extended release
Used for
ZetiaLovastatin
Risk factors for serious side effects
ZetiaLovastatin
    • Taking Zetia (Ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (Ezetimibe) with statins
    Detailed Zetia (Ezetimibe) risks & warnings »
    • Kidney disease
    • High dose of Mevacor (Lovastatin)
    • Combining with certain cholesterol-lowering drugs
    • Older age and female gender
    • Heavy alcohol use
    • History of chronic liver disease
    • Pregnancy
    • Breast feeding
    • Taking with certain drugs that increase the dose of Mevacor (Lovastatin) in the body
      Detailed Mevacor (Lovastatin) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Interactions
      ZetiaLovastatin
      No interactions related info.
      • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
      Alcohol
      ZetiaLovastatin
      No alcohol related info.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      Food
      ZetiaLovastatin
      No food related info.
      • Works best if you take it once a day after your evening meal.
      Kidneys and liver
      ZetiaLovastatin
      • Reports of liver disease have been reported in people who take Zetia (Ezetimibe), especially if taken with statins. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • There are rare cases of muscle damage leading to kidney failure in people taking Mevacor (Lovastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
      • There are reports of liver damage in people who take Mevacor (Lovastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
      Pain
      ZetiaLovastatin
      No pain related info.
      • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
      Upsides and benefits
      ZetiaLovastatin
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Can be used with other medicines to improve cholesterol.
      • Available in a combination pill with simvastatin.
      • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
      Downsides and risks
      ZetiaLovastatin
      • Doesn't lower triglycerides (fats).
      • Hasn't been shown to lower the risk of heart attacks or heart disease.
      • By itself, Zetia is not as effective as statins for improving cholesterol.
      • There's no generic available, so it can be expensive.
      • Not the best choice for people who have very high cholesterol levels.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      ZetiaLovastatin
      • Lowers bad cholesterol, and raises good cholesterol.
      • Tell your doctor if you develop bone or muscle pain.
      • Can be used with other medications to lower cholesterol.
      • May cause diarrhea or raise your chance of getting colds.
      • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
      • Most people reach their target cholesterol levels in 4 to 6 weeks.
      • Works best if you take it once a day after your evening meal.
      • Avoid grapefruit and grapefruit juice while taking this medicine.
      • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
      • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
      • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
      Learn more
      More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zetia (Ezetimibe)?
      Worth itNot sureNot worth it
      More about LovastatinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Mevacor (Lovastatin)?
      Worth itNot sureNot worth it