Compare Zetia vs. Niaspan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia (ezetimibe)

Prescription only

Niaspan (Niacin)

Prescription only
Lowers cholesterol.

Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.

4.4/ 7 average rating with 128 reviewsforZetia
Lowers cholesterol.

Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.

4.2/ 7 average rating with 380 reviewsforNiaspan
Upsides
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good for lowering triglycerides (fats).
Downsides
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
  • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
  • It can cause flushing and stomach pain or discomfort.
  • You need to take it before bedtime with a low-fat snack.
  • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Lowest price near you
$26.45
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Lowest price near you
$67.88
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Reviews
128 
42%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Zetia (ezetimibe)?

Leave a review
380 
43%
think this treatment is worth it
31%
think this treatment works well
19%
think this treatment is a hassle

Have you used Niaspan (Niacin)?

Leave a review
Side effects
8possible side effects
  • Diarrhea
    4%
  • Common cold
    4%
  • Sore throat
    4%
  • Sinus infection
    3%
  • Joint pain
    3%
  • Pain in arms and legs
    3%
  • Muscle pain
    3%
  • Abnormal liver tests
    3%
See more detailed side effects
6possible side effects
  • Flushing
    68%
  • Itching
    8%
  • Diarrhea
    7%
  • Nausea
    5%
  • Rash
    5%
  • Cough increased
    3%
See more detailed side effects
Risks and warnings
  • Muscle pain

    Taking Zetia (ezetimibe) with statins

  • Abnormal liver blood tests

    Past history of liver disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Muscle pain

    Taking Niaspan (Niacin) with statins

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • High blood sugar

    Diabetes

  • Low platelets

    Taking Niaspan (Niacin) with anticoagulants

  • Gout

    Gout

See more detailed risks and warnings