Compare Zetia vs. Niaspan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(ezetimibe)

Niaspan
(niacin)

Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.Lowers cholesterol. Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 30 (10mg) tablets of ezetimibe
Coupons for
Prices and coupon for 30 (500mg) tablets of niacin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Zetia
Reviews for Zetia (ezetimibe)
42%
of people (All ages) say Zetia (ezetimibe) is worth it
34%
say it works well
21%
say it's a big hassle
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Reviews for Niaspan (niacin)
43%
+1% better vs. Zetia (ezetimibe)
31%
-3% worse vs. Zetia (ezetimibe)
19%
+2% better vs. Zetia (ezetimibe)
380 reviews
Have you used Niaspan (niacin)?
Worth itNot sureNot worth it
Side effects
ZetiaNiaspan
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
  • Flushing 49%
  • Itching 6%
  • Rash 5%
More Niaspan side effects »
How it works
ZetiaNiaspan
Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.Niaspan (Niacin) is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver.
Type of medication
ZetiaNiaspan
Prescription only
Prescription only
Available as
ZetiaNiaspan
  • Pill
  • Pill
  • Extended release
Used for
ZetiaNiaspan
Risk factors for serious side effects
ZetiaNiaspan
    • Taking Zetia (ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (ezetimibe) with statins
    Detailed Zetia (ezetimibe) risks & warnings »
    • Taking Niaspan (Niacin) with statins
    • Heavy alcohol use
    • Past history of liver disease
    • Diabetes
    • Taking Niaspan (Niacin) with anticoagulants
    • Gout
    Detailed Niaspan (niacin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    ZetiaNiaspan
    No interactions related info.
    • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
    Alcohol
    ZetiaNiaspan
    No alcohol related info.
    • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
    Food
    ZetiaNiaspan
    No food related info.
    • You need to take it before bedtime with a low-fat snack.
    • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
    • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
    Kidneys and liver
    ZetiaNiaspan
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    No kidneys and liver related info.
    Pain
    ZetiaNiaspan
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    • It can cause flushing and stomach pain or discomfort.
    Upsides and benefits
    ZetiaNiaspan
    • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Can be used with other medicines to improve cholesterol.
    • Available in a combination pill with simvastatin.
    • Available as a generic.
    • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Good for lowering triglycerides (fats).
    Downsides and risks
    ZetiaNiaspan
    • Doesn't lower triglycerides (fats).
    • Hasn't been shown to lower the risk of heart attacks or heart disease.
    • By itself, it isn't as effective as statins for improving cholesterol.
    • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
    • It can cause flushing and stomach pain or discomfort.
    • You need to take it before bedtime with a low-fat snack.
    • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
    Tips from our pharmacists for people taking the medication
    ZetiaNiaspan
    • Lowers bad cholesterol and raises good cholesterol.
    • Tell your doctor if you develop bone or muscle pain.
    • Can be used with other medications to lower cholesterol.
    • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
    • Can cause diarrhea or increase your chance of getting colds.
    • Take Niaspan (Niacin) at bedtime with a low-fat snack.
    • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
    • Can cause make your skin feel hot and change color. Your doctor may tell you to take an aspirin 30 minutes before you take Niaspan (Niacin) to reduce the flushing.
    • Call your doctor if you feel unexplained muscle pain.
    • Niaspan (Niacin) works differently from other medicines you can buy over-the-counter. Don't switch it with other medicines unless your doctor agrees.
    Learn more
    More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zetia (ezetimibe)?
    Worth itNot sureNot worth it
    More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Niaspan (niacin)?
    Worth itNot sureNot worth it