Zetia vs. Omega 3 Acid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Omega-3 Acid)

Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.Lowers triglycerides. Omega-3 Acid is good for lowering triglycerides (fats), but some people can't take it due to allergies.
How it works
Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.Omega-3 Acid is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it may help the liver remove triglycerides from your body, and also prevent your body from making more triglycerides.
Type of medication
Cholesterol inhibitor
Prescription only
Omega-3 fatty acid
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zetia (Ezetimibe)
of people say Zetia (Ezetimibe) is worth it
say it works well
say it's a big hassle
Reviews for Lovaza (Omega-3 Acid)
+17% vs. Zetia (Ezetimibe)
+16% vs. Zetia (Ezetimibe)
-8% vs. Zetia (Ezetimibe)
Side effects
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
  • Eructation 3%
  • Indigestion 1%
More Omega 3 Acid side effects »
Risk factors for serious side effects
    • Taking Zetia (Ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (Ezetimibe) with statins
    Detailed Zetia (Ezetimibe) risks & warnings »
    • Allergy to fish or shellfish
    • Atrial fibrillation
    Detailed Lovaza (Omega-3 Acid) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.
    • You have to take it with food.
    • Take it with food.
    Kidneys and liver
    • People on Zetia (Ezetimibe) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Can be used with other medicines to improve cholesterol.
    • Available in a combination pill with simvastatin.
    • Lowers triglycerides (fats) when combined with exercise and a low cholesterol diet.
    • In studies, Omega-3 Acid has lowered the risk of stroke and heart attack leading to death, especially in people with high cholesterol or high triglycerides.
    Downsides and risks
    • Doesn't lower triglycerides (fats).
    • Hasn't been shown to lower the risk of heart attacks or heart disease.
    • By itself, Zetia is not as effective as statins for improving cholesterol.
    • There's no generic available, so it can be expensive.
    • You can't take it if you're allergic to fish or shellfish.
    • You have to take it with food.
    Tips from our pharmacists for people taking the medication
    • Lowers bad cholesterol, and raises good cholesterol.
    • Tell your doctor if you develop bone or muscle pain.
    • Can be used with other medications to lower cholesterol.
    • May cause diarrhea or raise your chance of getting colds.
    • Lowers triglycerides.
    • Take it with food.
    • Swallow capsules whole.
    • Can cause burping and changes in taste.
    • Don't use if you have an allergy to fish or shellfish.
    • You should use this medicine in combination with a healthy diet.
    Learn more
    More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
    More about Omega 3 AcidSide effectsReviews & ratingsAlternativesFDA package insert