Compare Zetia vs. simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(ezetimibe)

Zocor
(simvastatin)

Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.Lowers cholesterol. Zocor (simvastatin) is a good medication to improve your cholesterol.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Zetia
Reviews for Zetia
42%
of people (All ages) say Zetia is worth it
34%
say it works well
21%
say it's a big hassle
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Reviews for simvastatin
61%
-19% worse vs. Zetia
48%
-14% worse vs. Zetia
14%
-7% worse vs. Zetia
1176 reviews
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
Side effects
Zetiasimvastatin
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
  • Bronchitis 1%
  • Abnormal heart rhythm 1%
  • Scaly, itchy rash 2%
  • Stomach problems 1%
  • Balance problems 1%
  • Headache 1%
More simvastatin side effects »
How it works
Zetiasimvastatin
Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.Zocor (simvastatin) is cholesterol-lowering medicine called a statin. It helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
Zetiasimvastatin
Prescription onlyPrescription only
Available as
Zetiasimvastatin
  • Pill
  • Pill
Used for
Zetiasimvastatin
Risk factors for serious side effects
Zetiasimvastatin
  • Taking Zetia (ezetimibe) with statins
  • Past history of liver disease
Detailed Zetia (ezetimibe) risks & warnings »
  • Kidney disease
  • High dose of Zocor (simvastatin)
  • Combining Zocor (simvastatin) with other cholesterol-lowering drugs
  • Older age
  • Female gender
Detailed Zocor (simvastatin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Zetiasimvastatin
No interactions related info.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
  • Can have more drug interactions than some other drugs in the same class (statins).
Alcohol
Zetiasimvastatin
No alcohol related info.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
Zetiasimvastatin
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
  • People on Zocor (simvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you take higher doses of Zocor (simvastatin). If you suddenly feel muscle pain, weakness or fever and you haven't been exercising, stop taking Zocor (simvastatin) and talk to your doctor right away.
  • There are reports of liver damage in people who take Zocor (simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function regularly.
Pain
Zetiasimvastatin
No pain related info.
  • Combining certain medications can increase the risk of muscle pain, muscle damage, and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
Zetiasimvastatin
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
Downsides and risks
Zetiasimvastatin
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
Tips from our pharmacists for people taking the medication
Zetiasimvastatin
  • Lowers bad cholesterol and raises good cholesterol.
  • Tell your doctor if you develop bone or muscle pain.
  • Can be used with other medications to lower cholesterol.
  • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
  • Can cause diarrhea or increase your chance of getting colds.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
Learn more
More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
More about simvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it