Compare Zetia vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(ezetimibe)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Zetia
Reviews for Zetia
42%
of people (All ages) say Zetia is worth it
34%
say it works well
21%
say it's a big hassle
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Reviews for Trilipix
50%
-8% worse vs. Zetia
22%
+12% better vs. Zetia
25%
+4% better vs. Zetia
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Side effects
ZetiaTrilipix
  • Flu 1%
  • Joint pain 2%
  • Back pain 2%
  • Pain in arms and legs 2%
  • Gallbladder removal 2%
  • Sinus infection 1%
More Zetia side effects »
  • Fatigue 2%
  • Muscle Spasms 2%
  • Constipation 3%
  • Sinusitis 3%
  • Myalgia 3%
  • Diarrhea 4%
  • Dyspepsia 4%
  • Nausea 4%
  • Pain 4%
  • Nasopharyngitis 4%
More Trilipix side effects »
How it works
ZetiaTrilipix
Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
ZetiaTrilipix
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
ZetiaTrilipix
  • Pill
  • Pill
  • Extended release
Used for
ZetiaTrilipix
Risk factors for serious side effects
ZetiaTrilipix
  • Taking Zetia (ezetimibe) with statins
  • Past history of liver disease
Detailed Zetia (ezetimibe) risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed Trilipix (Fenofibric Acid) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
ZetiaTrilipix
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
Upsides and benefits
ZetiaTrilipix
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
Downsides and risks
ZetiaTrilipix
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
Tips from our pharmacists for people taking the medication
ZetiaTrilipix
  • Lowers bad cholesterol and raises good cholesterol.
  • Tell your doctor if you develop bone or muscle pain.
  • Can be used with other medications to lower cholesterol.
  • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
  • Can cause diarrhea or increase your chance of getting colds.
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it