Compare Zetia vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(Ezetimibe)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.393700787401575Zetia
Reviews for Zetia (Ezetimibe)
42%
of people (All ages) say Zetia (Ezetimibe) is worth it
34%
say it works well
20%
say it's a big hassle
127 reviews
Have you used Zetia (Ezetimibe)?
Worth itNot sureNot worth it
Reviews for Trilipix (Fenofibric Acid)
49%
+7% vs. Zetia (Ezetimibe)
22%
12% vs. Zetia (Ezetimibe)
25%
5% vs. Zetia (Ezetimibe)
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Side effects
ZetiaTrilipix
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
How it works
ZetiaTrilipix
Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
ZetiaTrilipix
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
ZetiaTrilipix
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
ZetiaTrilipix
Risk factors for serious side effects
ZetiaTrilipix
    • Taking Zetia (Ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (Ezetimibe) with statins
    Detailed Zetia (Ezetimibe) risks & warnings »
    • Taking Trilipix (Fenofibric Acid) with statins
    • Past history of liver disease
      • Taking Trilipix (Fenofibric Acid) with anticoagulants
                Detailed Trilipix (Fenofibric Acid) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Kidneys and liver
                ZetiaTrilipix
                • Reports of liver disease have been reported in people who take Zetia (Ezetimibe), especially if taken with statins. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
                • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
                Upsides and benefits
                ZetiaTrilipix
                • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Can be used with other medicines to improve cholesterol.
                • Available in a combination pill with simvastatin.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Good medicine for lowering triglycerides.
                Downsides and risks
                ZetiaTrilipix
                • Doesn't lower triglycerides (fats).
                • Hasn't been shown to lower the risk of heart attacks or heart disease.
                • By itself, Zetia is not as effective as statins for improving cholesterol.
                • There's no generic available, so it can be expensive.
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                Tips from our pharmacists for people taking the medication
                ZetiaTrilipix
                • Lowers bad cholesterol, and raises good cholesterol.
                • Tell your doctor if you develop bone or muscle pain.
                • Can be used with other medications to lower cholesterol.
                • May cause diarrhea or raise your chance of getting colds.
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                Learn more
                More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Zetia (Ezetimibe)?
                Worth itNot sureNot worth it
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Trilipix (Fenofibric Acid)?
                Worth itNot sureNot worth it