Compare Zetia vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zetia
(Ezetimibe)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.393700787401575Zetia
Reviews for Zetia (Ezetimibe)
42%
of people say Zetia (Ezetimibe) is worth it
34%
say it works well
20%
say it's a big hassle
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
+10% vs. Zetia (Ezetimibe)
36%
+2% vs. Zetia (Ezetimibe)
19%
+1% vs. Zetia (Ezetimibe)
Side effects
ZetiaVytorin
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
How it works
ZetiaVytorin
Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
ZetiaVytorin
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
ZetiaVytorin
  • Pill
  • Pill
Used for (click to learn more)
ZetiaVytorin
Risk factors for serious side effects
ZetiaVytorin
    • Taking Zetia (Ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (Ezetimibe) with statins
    Detailed Zetia (Ezetimibe) risks & warnings »
    • Asian patients taking high-dose niacin
    • Past history of liver disease
    • heavy alcohol use
    • Diabetes
        • Pregnancy
        Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
        Pregnancy category
        ZetiaVytorin
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • People on Zetia (Ezetimibe) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
        • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        ZetiaVytorin
        • Can be used with other medicines to improve cholesterol.
        • Available in a combination pill with simvastatin.
        • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • A 2-in-1 cholesterol-lowering combination medicine.
        • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        Downsides and risks
        ZetiaVytorin
        • Doesn't lower triglycerides (fats).
        • Hasn't been shown to lower the risk of heart attacks or heart disease.
        • By itself, Zetia is not as effective as statins for improving cholesterol.
        • There's no generic available, so it can be expensive.
        • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
        • There's no generic available, so it can be expensive.
        Tips from our pharmacists for people taking the medication
        ZetiaVytorin
        • Lowers bad cholesterol, and raises good cholesterol.
        • Tell your doctor if you develop bone or muscle pain.
        • Can be used with other medications to lower cholesterol.
        • May cause diarrhea or raise your chance of getting colds.
        • Take it in the evening.
        • Avoid grapefruit and grapefruit juice while taking this medicine.
        • Can cause headaches or diarrhea.
        • Call your doctor if you develop muscle pain.
        • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
        Learn more
        More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
        More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert