Compare Ziac vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ziac
(bisoprolol / hydrochlorothiazide)

Hyzaar
(losartan / hydrochlorothiazide)

Coming soon.Lowers blood pressure. Removes extra water from your body. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.
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Reviews & ratings
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Have you used Ziac (bisoprolol / hydrochlorothiazide)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Hyzaar (losartan / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
ZiacHyzaar

We haven’t found good data for Ziac side effects.

FDA side effect reports for Ziac »
  • Dizziness 3%
  • Upper respiratory infection 1%
  • Cough 1%
  • Back pain 1%
More Hyzaar side effects »
How it works
ZiacHyzaar
Coming soon.Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.
Type of medication
ZiacHyzaar
Prescription only
Available as
ZiacHyzaar
  • Pill
  • Pill
Used for
ZiacHyzaar
  • Hypertension
Risk factors for serious side effects
ZiacHyzaar
Coming soon.
  • Women of childbearing age
  • History of kidney problems
  • African descent
  • Current kidney problems
  • Medicine that affects potassium
  • Use of salt substitute
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
Detailed Hyzaar (losartan / hydrochlorothiazide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
ZiacHyzaar
No kidneys and liver related info.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Needs dose adjustment if you have liver problems.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Requires routine blood tests to check kidney function.
  • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
Upsides and benefits
ZiacHyzaar
Coming soon
  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.
Downsides and risks
ZiacHyzaar
Coming soon
  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.
Tips from our pharmacists for people taking the medication
ZiacHyzaar
Coming soon
  • Can cause dizziness in the first few days.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
  • Get immediate medical help if you notice any swelling, especially around your head and neck.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about ZiacSide effectsReviews & ratingsFDA package insert
Have you used Ziac (bisoprolol / hydrochlorothiazide)?
Worth itNot sureNot worth it
More about HyzaarSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Hyzaar (losartan / hydrochlorothiazide)?
Worth itNot sureNot worth it