Compare Zofran vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
How it works
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
Selective 5-HT3 antagonist
Prescription only
Anti-nausea, Antipsychotic
Prescription only
Available as
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Pill
  • Suppository
Used for (click to learn more)
Find lowest prices
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zofran (Ondansetron)
of people say Zofran (Ondansetron) is worth it
say it works well
say it's a big hassle
Reviews for Compro (Prochlorperazine)
21% vs. Zofran (Ondansetron)
15% vs. Zofran (Ondansetron)
20% vs. Zofran (Ondansetron)
Side effects
  • Fever 5%
  • Drowsiness 4%
  • Headache 2%
More Zofran side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
Risk factors for serious side effects
    • Long QT syndrome
    Detailed Zofran (Ondansetron) risks & warnings »
    • Over age 65
    • Dementia
    • Taking antipsychotics
    • History of seizures
    • Age over 65
        • Taking with alcohol
        • Taking other medicines that make you less alert
        Detailed Compro (Prochlorperazine) risks & warnings »
        Pregnancy category
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        No specific alcohol-related info.
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Don't drink alcohol to avoid intense side effects.
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Available in generic.
        • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
        • Starts working fast (in 30 minutes.
        • Available in generic, so it's cheap.
        • Can be taken by mouth, as a shot, or rectally.
        • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
        Downsides and risks
        • Can cause headaches.
        • Can interact with antidepressants.
        • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Can't be used by people over 65 because they can be more affected by the side effects.
        • It can make you more likely to get heatstroke.
        Tips from our pharmacists for people taking the medication
        • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
        • Can cause headache, fatigue or constipation.
        • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
        • It takes 30 minutes for Zofran to start working.
        • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        • Don't drink alcohol to avoid intense side effects.
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        • Avoid using if you experience seizures (epilepsy).
        • Don't use if you're 65 or older because you're at higher risk for serious side effects.
        Learn more
        More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
        More about ComproSide effectsReviews & ratingsAlternativesFDA package insert