Compare Zofran vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zofran
(ondansetron)

Compro
(prochlorperazine)

Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
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Prices and coupon for 30 (4mg) tablets of ondansetron
Coupons for
Prices and coupon for 30 (10mg) tablets of prochlorperazine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.91Zofran
Reviews for Zofran (ondansetron)
66%
of people (All ages) say Zofran (ondansetron) is worth it
51%
say it works well
15%
say it's a big hassle
366 reviews
Have you used Zofran (ondansetron)?
Worth itNot sureNot worth it

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Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it
Side effects
ZofranCompro
  • Headache 2%
  • Constipation 11%
  • Fever 5%
  • Increased ast and alt 5%
  • Drowsiness 4%
  • Itching 2%
  • Tingling sensation 2%
More Zofran side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
ZofranCompro
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ZofranCompro
Prescription only
Prescription only
Available as
ZofranCompro
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Pill
  • Suppository
Used for
ZofranCompro
Risk factors for serious side effects
ZofranCompro
    • Long QT syndrome
    Detailed Zofran (ondansetron) risks & warnings »
    • Over age 65
    • Dementia
    • Taking antipsychotics
    • History of seizures
    • Age over 65
        • Taking with alcohol
        • Taking other medicines that make you less alert
        Detailed Compro (prochlorperazine) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        Interactions
        ZofranCompro
        • Can interact with antidepressants.
        No interactions related info.
        Alcohol
        ZofranCompro
        No alcohol related info.
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Don't drink alcohol to avoid intense side effects.
        Pain
        ZofranCompro
        No pain related info.
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        Sleep
        ZofranCompro
        No sleep related info.
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        Upsides and benefits
        ZofranCompro
        • Available in generic.
        • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
        • Starts working fast (in 30 minutes.
        • Available in generic, so it's cheap.
        • Can be taken by mouth, as a shot, or rectally.
        • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
        Downsides and risks
        ZofranCompro
        • Can cause headaches.
        • Can interact with antidepressants.
        • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Can't be used by people over 65 because they can be more affected by the side effects.
        • It can make you more likely to get heatstroke.
        Tips from our pharmacists for people taking the medication
        ZofranCompro
        • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
        • Can cause headache, fatigue or constipation.
        • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
        • It takes 30 minutes for Zofran to start working.
        • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        • Don't drink alcohol to avoid intense side effects.
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        • Avoid using if you experience seizures (epilepsy).
        • Don't use if you're 65 or older because you're at higher risk for serious side effects.
        Learn more
        More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zofran (ondansetron)?
        Worth itNot sureNot worth it
        More about ComproSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Compro (prochlorperazine)?
        Worth itNot sureNot worth it