Compare Zofran vs. Compro
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.
Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
- Available in generic.
- Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
- Starts working fast (in 30 minutes.
- Available in generic, so it's cheap.
- Can be taken by mouth, as a shot, or rectally.
- Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
- Can cause headaches.
- Can interact with antidepressants.
- Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
- Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
- Can't be used by people over 65 because they can be more affected by the side effects.
- It can make you more likely to get heatstroke.
- Dissolving tablet
- Sublingual film
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- Increased AST and ALT5%
- Heart rhythm problems
Long QT syndrome
- Increased risk of death
Over age 65
...and 2 more risk factors
History of seizures
- Involuntary muscle movements
Age over 65
- Driving impairment
Taking with alcohol
...and 1 more risk factors