Compare Zofran vs. scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zofran
(ondansetron)

Transderm-Scop
(scopolamine)

Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Prevents nausea and vomiting. Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.
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Coupons for Zofran
Best available price for 30 (4mg) tablets of zofran
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.91Zofran
Reviews for Zofran
66%
of people (All ages) say Zofran is worth it
51%
say it works well
15%
say it's a big hassle
366 reviews
Have you used Zofran (ondansetron)?
Worth itNot sureNot worth it
Reviews for scopolamine
73%
-7% worse vs. Zofran
58%
-7% worse vs. Zofran
19%
+4% better vs. Zofran
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
Side effects
Zofranscopolamine
  • Headache 2%
  • Constipation 11%
  • Fever 5%
  • Increased ast and alt 5%
  • Drowsiness 4%
  • Itching 2%
  • Tingling sensation 2%
More Zofran side effects »
  • Dry mouth 12%
  • Dizziness 5%
  • Drowsiness 4%
  • Agitation 2%
  • Visual changes 2%
  • Confusion 1%
  • Dilated pupils 4%
  • Sore throat 1%
More scopolamine side effects »
How it works
Zofranscopolamine
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Transderm-Scop (scopolamine) is an anti-nausea medicine. It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
Zofranscopolamine
Prescription onlyPrescription only
Available as
Zofranscopolamine
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Patch
Used for
Zofranscopolamine
Risk factors for serious side effects
Zofranscopolamine
  • Long QT syndrome
Detailed Zofran (ondansetron) risks & warnings »
  • Open angle glaucoma
  • Blockages in the stomach, bowels or bladder
  • MRI examination
  • History of seizures
  • History of psychosis
Detailed Transderm-Scop (scopolamine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
Zofranscopolamine
  • Can interact with antidepressants.
No interactions related info.
Sleep
Zofranscopolamine
No sleep related info.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
Upsides and benefits
Zofranscopolamine
  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
Downsides and risks
Zofranscopolamine
  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
Tips from our pharmacists for people taking the medication
Zofranscopolamine
  • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
  • Can cause headache, fatigue or constipation.
  • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
  • It takes 30 minutes for Zofran to start working.
  • Starts working in 6 to 8 hours.
  • Apply Transderm-Scop (scopolamine) to a clean, dry, hairless area of the skin behind the ear. Press down for 30 seconds to make sure the patch stays firmly.
  • After handling the patch, make sure to wash your hands with soap and water to avoid accidental contact with your eyes.
  • If the patch comes off, throw it away and use a new patch.
  • You can prevent skin irritation by alternating ears and washing the area of your ear that you had placed the patch on.
  • If you're using this before surgery, place it the day before, then leave it on until the day after your surgery.
  • Take the patch off before you have an MRI because it can cause the skin to burn.
Learn more
More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zofran (ondansetron)?
Worth itNot sureNot worth it
More about scopolamineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it