Compare Zofran vs. Scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zofran
(Ondansetron)

Transderm-Scop
(Scopolamine)

Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.887323943661972Zofran
Reviews for Zofran (Ondansetron)
66%
of people say Zofran (Ondansetron) is worth it
50%
say it works well
15%
say it's a big hassle
Reviews for Transderm-Scop (Scopolamine)
72%
+6% vs. Zofran (Ondansetron)
56%
+6% vs. Zofran (Ondansetron)
20%
5% vs. Zofran (Ondansetron)
Side effects
ZofranScopolamine
  • Fever 5%
  • Drowsiness 4%
  • Headache 2%
More Zofran side effects »
  • Any side effect 9%
  • Drowsiness 4%
  • Visual impairment 2%
  • Agitation 2%
  • Confusion 1%
  • Sore throat 1%
More Scopolamine side effects »
How it works
ZofranScopolamine
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ZofranScopolamine
Anti-nausea
Selective 5-HT3 antagonist
Prescription only
Anti-nausea
Anticholinergic
Prescription only
Available as
ZofranScopolamine
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Patch
Used for (click to learn more)
ZofranScopolamine
Risk factors for serious side effects
ZofranScopolamine
    • Long QT syndrome
    Detailed Zofran (Ondansetron) risks & warnings »
    • Glaucoma
      • Doing an MRI
      • History of seizures
      • History of psychosis
      • Taking with alcohol
      • Taking other medicines that make you less alert
      Detailed Transderm-Scop (Scopolamine) risks & warnings »
      Pregnancy category
      ZofranScopolamine
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • You have to avoid alcohol while on the medication.
      • Don't drink alcohol if you have to use the patch.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      ZofranScopolamine
      • Available in generic.
      • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
      • Starts working fast (in 30 minutes.
      • Even though there's no generic version available, it's inexpensive.
      • Placed on the skin so it can be used if you can't keep anything in your stomach.
      • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
      Downsides and risks
      ZofranScopolamine
      • Can cause headaches.
      • Can interact with antidepressants.
      • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
      • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
      • Takes about 4 hours for it to start working.
      • You have to avoid alcohol while on the medication.
      Tips from our pharmacists for people taking the medication
      ZofranScopolamine
      • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
      • Can cause headache, fatigue or constipation.
      • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
      • It takes 30 minutes for Zofran to start working.
      • Wash your hands after you place the patch.
      • Don't touch or rub your eyes after putting on the patch before washing your hands.
      • Can cause blurry vision and sleepiness.
      • Take the patch off if you have to do an MRI.
      • Don't drink alcohol if you have to use the patch.
      • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
      Learn more
      More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
      More about ScopolamineSide effectsReviews & ratingsAlternativesFDA package insert