Compare Zofran vs. Scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zofran (Ondansetron)
of people say Zofran (Ondansetron) is worth it
say it works well
say it's a big hassle
Reviews for Transderm-Scop (Scopolamine)
+6% vs. Zofran (Ondansetron)
+6% vs. Zofran (Ondansetron)
5% vs. Zofran (Ondansetron)
Side effects
  • Fever 5%
  • Drowsiness 4%
  • Headache 2%
More Zofran side effects »
  • Any side effect 9%
  • Drowsiness 4%
  • Visual impairment 2%
  • Agitation 2%
  • Confusion 1%
  • Sore throat 1%
More Scopolamine side effects »
How it works
Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
Selective 5-HT3 antagonist
Prescription only
Prescription only
Available as
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Patch
Used for (click to learn more)
Risk factors for serious side effects
    • Long QT syndrome
    Detailed Zofran (Ondansetron) risks & warnings »
    • Glaucoma
      • Doing an MRI
      • History of seizures
      • History of psychosis
      • Taking with alcohol
      • Taking other medicines that make you less alert
      Detailed Transderm-Scop (Scopolamine) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.
      • You have to avoid alcohol while on the medication.
      • Don't drink alcohol if you have to use the patch.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • Available in generic.
      • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
      • Starts working fast (in 30 minutes.
      • Even though there's no generic version available, it's inexpensive.
      • Placed on the skin so it can be used if you can't keep anything in your stomach.
      • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
      Downsides and risks
      • Can cause headaches.
      • Can interact with antidepressants.
      • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
      • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
      • Takes about 4 hours for it to start working.
      • You have to avoid alcohol while on the medication.
      Tips from our pharmacists for people taking the medication
      • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
      • Can cause headache, fatigue or constipation.
      • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
      • It takes 30 minutes for Zofran to start working.
      • Wash your hands after you place the patch.
      • Don't touch or rub your eyes after putting on the patch before washing your hands.
      • Can cause blurry vision and sleepiness.
      • Take the patch off if you have to do an MRI.
      • Don't drink alcohol if you have to use the patch.
      • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
      Learn more
      More about ZofranSide effectsReviews & ratingsAlternativesFDA package insert
      More about ScopolamineSide effectsReviews & ratingsAlternativesFDA package insert