Compare Zoloft vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft (sertraline)

Prescription only

Anafranil (Clomipramine)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

4.7/ 7 average rating with 1472 reviewsforZoloft
Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$8.7
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Lowest price near you
$176.64
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Reviews
1472 
59%
think this treatment is worth it
41%
think this treatment works well
15%
think this treatment is a hassle

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Side effects
10possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
See more detailed side effects
8possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking other medicines that affect serotonin levels

  • Mania

    Personal history of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Zoloft (sertraline) suddenly

  • Increased bleeding

    Taking blood thinners

  • Low sodium levels in the blood

    Older people

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Seizure

    History of seizure

    ...and 2 more risk factors

  • Withdrawal

    Stopping Anafranil (Clomipramine) suddenly

  • Low blood pressure

    Age 65 years or older

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings