Compare Zoloft vs. Celexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(Sertraline)

Celexa
(Citalopram)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.690531177829099Zoloft
Reviews for Zoloft (Sertraline)
59%
of people (All ages) say Zoloft (Sertraline) is worth it
40%
say it works well
15%
say it's a big hassle
1299 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Reviews for Celexa (Citalopram)
60%
+1% vs. Zoloft (Sertraline)
50%
+10% vs. Zoloft (Sertraline)
15%
Same vs. Zoloft (Sertraline)
458 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Side effects
ZoloftCelexa
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
  • Drowsiness 8%
  • Nausea 7%
  • Dry mouth 6%
  • Abnormal ejaculation 5%
  • Ejaculation disorder 5%
  • Diarrhea 3%
  • Tremor 2%
  • Sweating increased 2%
  • Fatigue 2%
  • Loss of appetite 2%
More Celexa side effects »
How it works
ZoloftCelexa
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
ZoloftCelexa
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
ZoloftCelexa
  • Pill
  • Liquid
  • Pill
  • Oral solution
Used for (click to learn more)
ZoloftCelexa
Risk factors for serious side effects
ZoloftCelexa
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (Sertraline) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • History of bipolar disorder
      • At risk for bipolar disorder
      • Stopping Celexa (Citalopram) suddenly
      • Higher dose
      • History of heart problems
      • History of liver problems
      • Older age
      • Taking other blood-thinning drugs
        Detailed Celexa (Citalopram) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        ZoloftCelexa
        • It interacts with St. John's Wort and Tryptophan.
        No interactions related info.
        Food
        ZoloftCelexa
        No food related info.
        • Take with food to avoid upset stomach.
        Kidneys and liver
        ZoloftCelexa
        No kidneys and liver related info.
        • Not a good option for you if you have heart or liver problems.
        Sex
        ZoloftCelexa
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        ZoloftCelexa
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        No sleep related info.
        Weight
        ZoloftCelexa
        No weight related info.
        • Can cause minor weight gain (1 to 5 pounds).
        Upsides and benefits
        ZoloftCelexa
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving depression and anxiety symptoms.
        • Causes less sleepiness compared to other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        ZoloftCelexa
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Can cause minor weight gain (1 to 5 pounds).
        • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
        • Not a good option for you if you have heart or liver problems.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        ZoloftCelexa
        • It interacts with St. John's Wort and Tryptophan.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Take with food to avoid upset stomach.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (Sertraline)?
        Worth itNot sureNot worth it
        More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Celexa (Citalopram)?
        Worth itNot sureNot worth it