Compare Zoloft vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(sertraline)

Klonopin
(clonazepam)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.
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Prices and coupon for 30 (100mg) tablets of sertraline
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Prices and coupon for 60 (0.5mg) tablets of clonazepam
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Zoloft
Reviews for Zoloft (sertraline)
59%
of people (All ages) say Zoloft (sertraline) is worth it
41%
say it works well
15%
say it's a big hassle
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Reviews for Klonopin (clonazepam)
70%
+11% better vs. Zoloft (sertraline)
52%
+11% better vs. Zoloft (sertraline)
14%
+1% better vs. Zoloft (sertraline)
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Side effects
ZoloftKlonopin
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »
How it works
ZoloftKlonopin
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
ZoloftKlonopin
Prescription only
Prescription only
Available as
ZoloftKlonopin
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Used for
ZoloftKlonopin
Risk factors for serious side effects
ZoloftKlonopin
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (sertraline) risks & warnings »
      • Taking more than the prescribed dose
      • Taking longer than 4 weeks
      • History of drug abuse
      • Long-term use
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Klonopin (clonazepam) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          ZoloftKlonopin
          • It interacts with St. John's Wort and Tryptophan.
          No interactions related info.
          Alcohol
          ZoloftKlonopin
          No alcohol related info.
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Not safe to use with alcohol.
          Sex
          ZoloftKlonopin
          • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
          No sex related info.
          Sleep
          ZoloftKlonopin
          • Causes less drowsiness than other antidepressants.
          • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can cause dizziness, drowsiness, and salivation.
          Upsides and benefits
          ZoloftKlonopin
          • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
          • Causes less drowsiness than other antidepressants.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          • Effective at relieving short-term anxiety and sleeplessness.
          • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
          • Can be used alone or with other medicines to treat seizures.
          • Less severe withdrawal symptoms compared to other benzodiazepines.
          Downsides and risks
          ZoloftKlonopin
          • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
          • More likely to cause diarrhea than other antidepressants.
          • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Most people find that it gets less effective over time.
          Tips from our pharmacists for people taking the medication
          ZoloftKlonopin
          • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
          • It interacts with St. John's Wort and Tryptophan.
          • Stop taking it slowly to avoid getting withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • For the first week, avoid activities that require you to be alert.
          • Can cause dizziness, drowsiness, and salivation.
          • Report any confusion or inability to control muscle movements to your doctor.
          • Not safe to use with alcohol.
          Learn more
          More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Zoloft (sertraline)?
          Worth itNot sureNot worth it
          More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Klonopin (clonazepam)?
          Worth itNot sureNot worth it