Compare Zoloft vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft (sertraline)

Prescription only

Klonopin (Clonazepam)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

4.7/ 7 average rating with 1472 reviewsforZoloft
Controls seizures and helps you relax.

Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.

5.2/ 7 average rating with 767 reviewsforKlonopin
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Can be used alone or with other medicines to treat seizures.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Price
Lowest price near you
$8.7
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Lowest price near you
$7.39
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Reviews
1472 
59%
think this treatment is worth it
41%
think this treatment works well
15%
think this treatment is a hassle

Have you used Zoloft (sertraline)?

Leave a review
767 
70%
think this treatment is worth it
52%
think this treatment works well
14%
think this treatment is a hassle

Have you used Klonopin (Clonazepam)?

Leave a review
Side effects
10possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
See more detailed side effects
10possible side effects
  • Somnolence
    37%
  • Dizziness
    8%
  • Upper Respiratory Tract Infection
    8%
  • Depression
    7%
  • Fatigue
    7%
  • Coordination Abnormal
    6%
  • Ataxia
    5%
  • Memory Disturbance
    4%
  • Sinusitis
    4%
  • Influenza
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking other medicines that affect serotonin levels

  • Mania

    Personal history of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Zoloft (sertraline) suddenly

  • Increased bleeding

    Taking blood thinners

  • Low sodium levels in the blood

    Older people

    ...and 1 more risk factors

See more detailed risks and warnings
  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Withdrawal

    Long-term use

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings