Compare Zoloft vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(Sertraline)

Oleptro
(Trazodone)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Zoloft
Reviews for Zoloft (Sertraline)
59%
of people (All ages) say Zoloft (Sertraline) is worth it
41%
say it works well
15%
say it's a big hassle
1472 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Reviews for Oleptro (Trazodone)
73%
+14% vs. Zoloft (Sertraline)
49%
+8% vs. Zoloft (Sertraline)
24%
9% vs. Zoloft (Sertraline)
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Side effects
ZoloftOleptro
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »

The Oleptro FDA package insert doesn’t have numbers about how common side effects are.

More about Oleptro side effects »
How it works
ZoloftOleptro
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
ZoloftOleptro
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
ZoloftOleptro
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
ZoloftOleptro
Risk factors for serious side effects
ZoloftOleptro
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ZoloftOleptro
  • It interacts with St. John's Wort and Tryptophan.
No interactions related info.
Sex
ZoloftOleptro
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Sleep
ZoloftOleptro
  • Causes less drowsiness than other antidepressants.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
No sleep related info.
Upsides and benefits
ZoloftOleptro
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
ZoloftOleptro
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
ZoloftOleptro
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it