Compare Zoloft vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft (sertraline)

Prescription only

Prozac (fluoxetine)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

3.5/ 5 average rating with 1472 reviewsforZoloft
Improves mood and helps you relax.

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

3.5/ 5 average rating with 1319 reviewsforProzac
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Delayed-release pill
  • Liquid
Price
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Reviews
1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

Have you used Zoloft (sertraline)?

Leave a review
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Prozac (fluoxetine)?

Leave a review
Side effects
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
22possible side effects
  • Inability to sleep
    33%
  • Nausea
    28%
  • Lack of energy
    21%
  • Anxiety
    15%
  • Sleepiness
    13%
  • Tremor
    13%
  • Nervousness
    11%
  • Yawn
    11%
  • Indigestion
    10%
  • Sore throat
    10%
  • Dry mouth
    9%
  • Flu syndrome
    8%
  • Diarrhea
    8%
  • Loss of appetite
    8%
  • Sweating
    8%
  • Impotence
    7%
  • Abnormal ejaculation
    7%
  • Sinus infection
    6%
  • Lower sex drive
    5%
  • Abnormal dreams
    5%
  • Rash
    4%
  • Widening of blood vessels
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Ultram
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
    • St. John's Wort
  • Skin rash
  • Weight loss
    • People with an eating disorder
  • Increased bleeding risk
    • Taking NSAIDS or blood-thinning drugs
  • Abnormal heart rhythm
    • People with heart rhythm problems or a family history of them
    • Low potassium level
    • Low magnesium level
    • Recent heart attack
    • Using other drugs that affect heart rhythm
    • Overdose
    • People with liver problems
See more detailed risks and warnings