Compare Zoloft vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(Sertraline)

Remeron
(Mirtazapine)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.690531177829099Zoloft
Reviews for Zoloft (Sertraline)
59%
of people say Zoloft (Sertraline) is worth it
40%
say it works well
15%
say it's a big hassle
Reviews for Remeron (Mirtazapine)
47%
12% vs. Zoloft (Sertraline)
42%
+2% vs. Zoloft (Sertraline)
26%
11% vs. Zoloft (Sertraline)
Side effects
ZoloftRemeron
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
ZoloftRemeron
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
ZoloftRemeron
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
ZoloftRemeron
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Used for (click to learn more)
ZoloftRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
ZoloftRemeron
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (Sertraline) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • History of heart problems
      • History of liver problems
      • Higher dose
      • Alcohol
      • Taking other medicines that make you less alert
          Detailed Remeron (Mirtazapine) risks & warnings »
          Pregnancy category
          ZoloftRemeron
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
          No specific sex-related info.
          Sleep
          • Causes less drowsiness than other antidepressants.
          No specific sleep-related info.
          Weight
          No specific weight-related info.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Can increase appetite and weight.
          • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
          Upsides and benefits
          ZoloftRemeron
          • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
          • Causes less drowsiness than other antidepressants.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          • Effective at relieving some depression symptoms.
          • Starts to work more quickly than most antidepressants.
          • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          Downsides and risks
          ZoloftRemeron
          • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
          • More likely to cause diarrhea than other antidepressants.
          • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          • Not as effective as other medications for depression.
          • More sedating than other antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          Tips from our pharmacists for people taking the medication
          ZoloftRemeron
          • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
          • It interacts with St. John's Wort and Tryptophan.
          • Stop taking it slowly to avoid getting withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • Makes you sleepy. Take at bedtime.
          • Can increase appetite and weight.
          • Takes 8 to 12 weeks to see full effects on mood.
          • Stop taking slowly to avoid withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          Learn more
          More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
          More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert