Compare Zoloft vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(Sertraline)

Remeron
(mirtazapine)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Zoloft
Reviews for Zoloft
59%
of people (All ages) say Zoloft is worth it
41%
say it works well
15%
say it's a big hassle
1472 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
+14% better vs. Zoloft
39%
+2% better vs. Zoloft
26%
+11% better vs. Zoloft
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
ZoloftRemeron
  • Anorexia 1%
  • Dyspepsia 3%
  • Agitation 2%
  • Ejaculation Failure 7%
  • Sweating Increased 5%
  • Constipation 2%
  • Tremor 8%
  • Fatigue 3%
  • Dizziness 5%
More Zoloft side effects »
  • Back pain 1%
  • Swelling in limbs 1%
  • Muscle pain 1%
  • Tremor 1%
  • Confusion 2%
  • Urinary frequency 1%
  • Abnormal thinking 2%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Dizziness 4%
More Remeron side effects »
How it works
ZoloftRemeron
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
ZoloftRemeron
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
ZoloftRemeron
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Used for
ZoloftRemeron
Risk factors for serious side effects
ZoloftRemeron
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (Sertraline) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ZoloftRemeron
  • It interacts with St. John's Wort and Tryptophan.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
Sex
ZoloftRemeron
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Sleep
ZoloftRemeron
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Can help you fall asleep if you have trouble sleeping.
  • Makes you more tired than other antidepressants.
Weight
ZoloftRemeron
No weight related info.
  • Remeron (mirtazapine) can raise your appetite and cause you to gain weight. Remeron (mirtazapine) can also raise your cholesterol.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Upsides and benefits
ZoloftRemeron
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides and risks
ZoloftRemeron
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Tips from our pharmacists for people taking the medication
ZoloftRemeron
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • You should not abruptly stop Remeron (mirtazapine) as this could cause serious side effects.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
  • Remeron (mirtazapine) should be protected from light. Keep it in it's original package until ready to use.
  • Remeron (mirtazapine) can cause dry mouth. Try using sugar-free gum or candy to help with dry mouth.
Learn more
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it