Compare Zoloft vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft
(Sertraline)

Viibryd
(Vilazodone)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.690531177829099Zoloft
Reviews for Zoloft (Sertraline)
59%
of people say Zoloft (Sertraline) is worth it
40%
say it works well
15%
say it's a big hassle
Reviews for Viibryd (Vilazodone)
67%
+8% vs. Zoloft (Sertraline)
59%
+19% vs. Zoloft (Sertraline)
13%
+2% vs. Zoloft (Sertraline)
Side effects
ZoloftViibryd
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
  • Diarrhea 19%
  • Nausea 18%
  • Vomiting 4%
  • Dizziness 4%
  • Sleep difficulty 4%
  • Dry mouth 3%
  • Abnormal dreams 3%
  • Tingling sensation 2%
  • Fatigue 1%
  • Impotence 1%
More Viibryd side effects »
How it works
ZoloftViibryd
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
ZoloftViibryd
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Partial serotonin receptor agonist
Prescription only
Available as
ZoloftViibryd
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
ZoloftViibryd
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Viibryd (Vilazodone)
Risk factors for serious side effects
ZoloftViibryd
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (Sertraline) risks & warnings »
      • Age 18 years or younger
      • Taking Viibryd (Vilazodone) with MAOIs
      • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
      • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
      • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
      • Women of childbearing age
      • History of glaucoma
      • History of bipolar disorder (mixed/mania)
      Detailed Viibryd (Vilazodone) risks & warnings »
      Pregnancy category
      ZoloftViibryd
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
      Food
      No specific food-related info.
      • Take Viibryd (Vilazodone) with food at the same time every day.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
      Sex
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
      Sleep
      • Causes less drowsiness than other antidepressants.
      • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
      Weight
      No specific weight-related info.
      • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
      Upsides and benefits
      ZoloftViibryd
      • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
      • Causes less drowsiness than other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
      • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
      • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
      Downsides and risks
      ZoloftViibryd
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • More likely to cause diarrhea than other antidepressants.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
      • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
      • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
      Tips from our pharmacists for people taking the medication
      ZoloftViibryd
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • It interacts with St. John's Wort and Tryptophan.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Take Viibryd (Vilazodone) with food at the same time every day.
      • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
      • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
      • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
      • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
      Learn more
      More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
      More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert