Compare Zoloft vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zoloft (sertraline)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

4.7/ 7 average rating with 1472 reviewsforZoloft
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

5.4/ 7 average rating with 95 reviewsforViibryd
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$8.7
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Lowest price near you
$240.4
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Reviews
1472 
59%
think this treatment is worth it
41%
think this treatment works well
15%
think this treatment is a hassle

Have you used Zoloft (sertraline)?

Leave a review
95 
67%
think this treatment is worth it
63%
think this treatment works well
13%
think this treatment is a hassle

Have you used Viibryd (Vilazodone)?

Leave a review
Side effects
10possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
See more detailed side effects
10possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking other medicines that affect serotonin levels

  • Mania

    Personal history of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Zoloft (sertraline) suddenly

  • Increased bleeding

    Taking blood thinners

  • Low sodium levels in the blood

    Older people

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 18 years or younger

  • Monoamine oxidase inhibitor (MAOI) interaction

    Taking Viibryd (Vilazodone) with MAOIs

    ...and 1 more risk factors

  • Serotonin syndrome

    Taking Viibryd (Vilazodone) with other drugs that increase serotonin

  • Abnormal bleeding

    Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting

  • Risk to fetus

    Women of childbearing age

  • Eye problems

    History of glaucoma

  • Activation of mania/hypomania

    History of bipolar disorder (mixed/mania)

See more detailed risks and warnings