Compare Zoloft vs. Wellbutrin

Zoloft (Sertraline) and Wellbutrin (Bupropion) are both antidepressants for treating depression. Zoloft is a Selective serotonin reuptake inhibitor (SSRI) that affects chemicals in the brain; it is also good for treating anxiety, and is more likely to insomnia and diarrhea than other antidepressants. Wellbutrin has a different mechanism on your brain chemistry; it has fewer sexual side effects than other antidepressants but may cause seizures if you drink a lot of alcohol.

Zoloft
(sertraline)

Wellbutrin
(bupropion)

Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.
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Prices and coupon for 30 (100mg) tablets of sertraline
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Prices and coupon for 60 (75mg) tablets of bupropion
Reviews & ratings
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Filter group. All currently selected
4.74Zoloft
Reviews for Zoloft (sertraline)
59%
of people (All ages) say Zoloft (sertraline) is worth it
41%
say it works well
15%
say it's a big hassle
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Reviews for Wellbutrin (bupropion)
60%
+1% better vs. Zoloft (sertraline)
40%
-1% worse vs. Zoloft (sertraline)
13%
+2% better vs. Zoloft (sertraline)
1164 reviews
Have you used Wellbutrin (bupropion)?
Worth itNot sureNot worth it
Side effects
ZoloftWellbutrin
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
  • Agitation 10%
  • Dry mouth 10%
  • Headache/migraine 4%
  • Constipation 9%
  • Nausea/vomiting 4%
  • Excessive sweating 7%
  • Dizziness 6%
  • Tremor 13%
  • Sleep difficulty 3%
More Wellbutrin side effects »
How it works
ZoloftWellbutrin
Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.
Type of medication
ZoloftWellbutrin
Prescription only
Prescription only
Available as
ZoloftWellbutrin
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for
ZoloftWellbutrin
Risk factors for serious side effects
ZoloftWellbutrin
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (sertraline) risks & warnings »
      • Age 24 years or younger
      • History of depression
      • History of bipolar disorder
      • At risk for bipolar disorder
      • Withdrawing from nicotine
      • History of seizures
      • Alcoholism
      • Eating disorder
      • Higher dose
      • Drug interactions
      • History of bipolar disorder
      • At risk for bipolar disorder
      • Current kidney problems
      • Current liver problems
        Detailed Wellbutrin (bupropion) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        ZoloftWellbutrin
        • It interacts with St. John's Wort and Tryptophan.
        No interactions related info.
        Alcohol
        ZoloftWellbutrin
        No alcohol related info.
        • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
        Kidneys and liver
        ZoloftWellbutrin
        No kidneys and liver related info.
        • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
        Sex
        ZoloftWellbutrin
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        No sex related info.
        Sleep
        ZoloftWellbutrin
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        No sleep related info.
        Weight
        ZoloftWellbutrin
        No weight related info.
        • It's less likely to cause weight gain than other antidepressants.
        Upsides and benefits
        ZoloftWellbutrin
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving depression symptoms.
        • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
        • Can be taken with other antidepressants to counteract their sexual side effects.
        • Has some stimulant effects, so it can be energizing.
        • Can help with ADHD symptoms.
        • Also used to suppress appetite and help you quit smoking.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        ZoloftWellbutrin
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
        • Generally not as good as other antidepressants for people who have anxiety.
        • It's less likely to cause weight gain than other antidepressants.
        • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
        • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        ZoloftWellbutrin
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • It interacts with St. John's Wort and Tryptophan.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • There are no sexual side effects from this medication.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
        Learn more
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (sertraline)?
        Worth itNot sureNot worth it
        More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Wellbutrin (bupropion)?
        Worth itNot sureNot worth it