Compare Zomig vs. Amerge

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zomig
(zolmitriptan)

Amerge
(naratriptan)

Treats migraines. Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.Treats migraine headaches. Amerge (naratriptan) isn't as good as other similar medications for migraines, but can be good if other drugs haven't worked for you.
Reviews & ratings
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Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it

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Have you used Amerge (naratriptan)?
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Side effects
ZomigAmerge
  • Nervous system problems 7%
  • Stomach problems 8%
  • Pain and pressure sensation 7%
  • Unusual sensations 6%
  • Nausea 5%
  • Dizziness 4%
  • Tingling or prickling sensation 5%
  • Neck, throat or jaw pain/pressure 4%
  • Sleepiness 3%
  • Warm or cold sensation 1%
More Zomig side effects »
  • Stomach problems 1%
  • Nervous system issues 1%
  • Unusual sensation 1%
  • Fatigue or uneasiness 1%
  • Tingling or prickling sensation 2%
  • Dizziness 1%
  • Drowsiness 2%
  • Pain & pressure in throat or neck 1%
More Amerge side effects »
How it works
ZomigAmerge
Zomig (zolmitriptan) is a triptan. It prevents the enlargement of blood vessels in your brain, which causes migraines.Amerge (naratriptan) is a selective serotonin receptor agonist or triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Amerge (naratriptan) tightens the blood vessels which relieves the pain.
Type of medication
ZomigAmerge
Prescription onlyPrescription only
Available as
ZomigAmerge
  • Pill
  • Dissolving tablet
  • Nasal spray
  • Pill
Used for
ZomigAmerge
Risk factors for serious side effects
ZomigAmerge
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
Detailed Zomig (zolmitriptan) risks & warnings »
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Amerge (naratriptan) for more than 10 days a month
Detailed Amerge (naratriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
ZomigAmerge
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
  • Amerge (naratriptan) is a good alternative to other triptans since it's less likely to cause side effects and if other triptans haven't worked for you.
  • Available as a generic, which makes it cheaper than other medicines and is more likely to be covered by insurances.
  • Amerge (naratriptan) comes in two different strengths.
Downsides and risks
ZomigAmerge
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
  • Amerge (naratriptan) is only available as a pill that must be swallowed, so it might not be good if you have trouble swallowing when you have a migraine.
  • Unlike other migraine medications, you have to wait for 4 hours before you can take the second dose of Amerge (naratriptan).
  • Amerge (naratriptan) is not as good as other medications for treating nausea that can happen with migraines.
Tips from our pharmacists for people taking the medication
ZomigAmerge
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 10 mg total in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
  • Amerge (naratriptan) can only treat a migraine that's already happening. Amerge (naratriptan) doesn't prevent migraines.
  • Take Amerge (naratriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 4 hours. Don't take more than two doses every 24 hours.
  • Amerge (naratriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you finish the entire month's supply of Amerge (naratriptan) before it's time for your next refill, or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
  • Amerge (naratriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
Learn more
More about ZomigSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zomig (zolmitriptan)?
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More about AmergeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it