Compare Zomig vs. Cafergot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats migraines.

Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.

Treats migraine headaches.

Cafergot (ergotamine / caffeine) can treat migraines, but you're more likely to have side effects.

Upsides
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
  • Cafergot (ergotamine / caffeine) works better than other medicines if your migraines usually last more than 2 days or if you have more frequent migraines.
Downsides
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
  • Cafergot (ergotamine / caffeine) can't stop migraines from happening. They can only treat them.
  • Cafergot (ergotamine / caffeine) can only be used for migraines. It doesn't work for other types of headaches.
  • Smoking or using products that contain nicotine can make Cafergot (ergotamine / caffeine) less effective.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Nasal spray
  • Pill
  • Suppository
Price
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Reviews
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Side effects
12possible side effects
  • Changes in taste
    21%
  • Tingling or prickling sensation
    10%
  • Oversensitivity of the skin
    5%
  • Pain
    4%
  • Pain in the throat
    4%
  • Nausea
    4%
  • Sleepiness
    4%
  • Discomfort in the nose
    3%
  • Dizziness
    3%
  • Weakness
    3%
  • Tightness in the throat
    2%
  • Dry mouth
    2%
See more detailed side effects
The Cafergot (ergotamine / caffeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack
    • Heart disease
    • history of chest pain/angina
    • uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
  • Changes in heartbeat
    • History of arrhythmia
  • Serotonin syndrome
    • Taking tricyclic antidepressants, fentanyl, tramadol, buspirone, or ADHD medicines
  • Blood vessel issues
    • High blood pressure
    • history of stroke
See more detailed risks and warnings
  • Heart and circulation problems
    • Overdosing Cafergot (ergotamine / caffeine)
    • Taking triptans (Imitrex, Axert, Maxalt, Amerge, Frova) for migraines
  • Dependency and withdrawal
    • Taking Cafergot (ergotamine / caffeine) regularly for months
  • Danger to fetus
See more detailed risks and warnings