Compare Zomig vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats migraines. Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.
Reviews & ratings
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Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Side effects
  • Nervous system problems 7%
  • Stomach problems 8%
  • Pain and pressure sensation 7%
  • Unusual sensations 6%
  • Nausea 5%
  • Dizziness 4%
  • Tingling or prickling sensation 5%
  • Neck, throat or jaw pain/pressure 4%
  • Sleepiness 3%
  • Warm or cold sensation 1%
More Zomig side effects »
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
How it works
Zomig (zolmitriptan) is a triptan. It prevents the enlargement of blood vessels in your brain, which causes migraines.Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Dissolving tablet
  • Nasal spray
  • Nasal powder
Used for
Risk factors for serious side effects
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
Detailed Zomig (zolmitriptan) risks & warnings »
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
Detailed Onzetra (sumatriptan) risks & warnings »

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides and risks
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Tips from our pharmacists for people taking the medication
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 10 mg total in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
Learn more
More about ZomigSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it