Compare Zomig vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zomig
(Zolmitriptan)

Onzetra
(sumatriptan)

Coming soon.Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.
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Reviews & ratings
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Have you used Zomig (Zolmitriptan)?
Worth itNot sureNot worth it

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Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Side effects
ZomigOnzetra

We haven’t found good data for Zomig side effects.

FDA side effect reports for Zomig »
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
How it works
ZomigOnzetra
Coming soon.Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.
Type of medication
ZomigOnzetra
Prescription only
Available as
ZomigOnzetra
  • Pill
  • Dissolving tablet
  • Nasal spray
  • Nasal powder
Used for
ZomigOnzetra
  • Migraine Acute
Risk factors for serious side effects
ZomigOnzetra
Coming soon.
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
  • ADHD medicines
  • Triptans
  • Uncontrolled high blood pressure
  • Taking medicines for seizures
  • High blood pressure
  • History of stroke
Detailed Onzetra (sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
ZomigOnzetra
Coming soon
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides and risks
ZomigOnzetra
Coming soon
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Tips from our pharmacists for people taking the medication
ZomigOnzetra
Coming soon
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
Learn more
More about ZomigSide effectsReviews & ratingsFDA package insert
Have you used Zomig (Zolmitriptan)?
Worth itNot sureNot worth it
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it