Compare Zyban vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyban (Bupropion)

Prescription only

Pamelor (Nortriptyline)

Prescription only
Reduces nicotine cravings.

Good for blocking the withdrawal symptoms of quitting smoking. But you need to be okay with avoiding alcohol use and possibly using nicotine replacement.

Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
  • Can help relieve the withdrawal symptoms associated with smoking.
  • Fewer sexual side effects compared to other antidepressants. Can actually boost sex drive for some people.
  • Zyban (Bupropion) does not contain nicotine, so it is not dangerous if you continue to smoke. You can even use nicotine replacement like the patch while you are taking Zyban (Bupropion)
  • Has some stimulant effects, so it can be energizing.
  • Six out of every 10 people who use an antidepressant for the first time find that it works for them.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Can be stimulating, so it can cause some anxiety or insomnia in the first few days.
  • Higher risk of seizures, especially if you have a seizure disorder or eating disorder, or if you drink alcohol.
  • Not a good medication for you if you drink a lot.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • If you are a heavy smoker you may also need to use nicotine replacement like the patch.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Liquid
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Side effects
10possible side effects
  • Insomnia
  • Dry mouth
  • Dizziness
  • Arthralgia
  • Pruritus
  • Rash
  • Neck pain
  • Increased appetite
  • Myalgia
  • Tremor
See more detailed side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Psychiatric effects for quitting smoking

    History of depression

    ...and 3 more risk factors

  • Suicidal thoughts or behavior

    Age 24 and younger

  • Seizures

    Those taking large doses

  • Hypertension

    Those taking MAOIs or using a nicotine patch

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings