Compare Zyprexa vs. chlorpromazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(olanzapine)

Thorazine
(chlorpromazine)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.
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Coupons for Zyprexa
Best available price for 30 (5mg) tablets of olanzapine
Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Reviews & ratings
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5.09Zyprexa
Reviews for Zyprexa (olanzapine)
41%
of people (All ages) say Zyprexa (olanzapine) is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Reviews for Thorazine (chlorpromazine)
Not enough review data. Review it!
-41% worse vs. Zyprexa (olanzapine)
Not enough review data. Review it!
-51% worse vs. Zyprexa (olanzapine)
Not enough review data. Review it!
+51% better vs. Zyprexa (olanzapine)
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Side effects
Zyprexachlorpromazine
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Positional low blood pressure 3%
  • Restlessness 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Muscle weakness 9%
  • Indigestion 6%
More Zyprexa side effects »

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
How it works
Zyprexachlorpromazine
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.
Type of medication
Zyprexachlorpromazine
Prescription only
Prescription only
Available as
Zyprexachlorpromazine
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Injection
Used for
Zyprexachlorpromazine
Risk factors for serious side effects
Zyprexachlorpromazine
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Zyprexachlorpromazine
No alcohol related info.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
Food
Zyprexachlorpromazine
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
Zyprexachlorpromazine
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
Weight
Zyprexachlorpromazine
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No weight related info.
Upsides and benefits
Zyprexachlorpromazine
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
Downsides and risks
Zyprexachlorpromazine
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
Tips from our pharmacists for people taking the medication
Zyprexachlorpromazine
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it