Compare Zyprexa vs. fluphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(olanzapine)

Prolixin
(fluphenazine)

Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyprexa
Reviews for Zyprexa
41%
of people (All ages) say Zyprexa is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it

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Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
Side effects
Zyprexafluphenazine
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Weakness 9%
  • Stomach problems 6%
More Zyprexa side effects »

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »
How it works
Zyprexafluphenazine
Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
Zyprexafluphenazine
Prescription onlyPrescription only
Available as
Zyprexafluphenazine
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
Zyprexafluphenazine
Risk factors for serious side effects
Zyprexafluphenazine
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Zyprexafluphenazine
No alcohol related info.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Sleep
Zyprexafluphenazine
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
Zyprexafluphenazine
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
No weight related info.
Upsides and benefits
Zyprexafluphenazine
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
Downsides and risks
Zyprexafluphenazine
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
Tips from our pharmacists for people taking the medication
Zyprexafluphenazine
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it