Compare Zyprexa vs. Geodon

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(olanzapine)

Geodon
(ziprasidone)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.
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Coupons for Zyprexa
Best available price for 30 (5mg) tablets of olanzapine
Coupons for Geodon
Best available price for 30 (40mg) capsules of ziprasidone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyprexa
Reviews for Zyprexa (olanzapine)
41%
of people (All ages) say Zyprexa (olanzapine) is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Reviews for Geodon (ziprasidone)
43%
+2% better vs. Zyprexa (olanzapine)
43%
-8% worse vs. Zyprexa (olanzapine)
30%
+21% better vs. Zyprexa (olanzapine)
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it
Side effects
ZyprexaGeodon
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Positional low blood pressure 3%
  • Restlessness 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Muscle weakness 9%
  • Indigestion 6%
More Zyprexa side effects »
  • Extrapyramidal symptoms 6%
  • Drowsiness 7%
  • Nausea 3%
  • Constipation 1%
  • Respiratory tract infection 5%
  • Dizziness 2%
  • Indigestion 1%
  • Restlessness 1%
  • Muscle weakness 2%
  • Diarrhea 1%
More Geodon side effects »
How it works
ZyprexaGeodon
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
ZyprexaGeodon
Prescription only
Prescription only
Available as
ZyprexaGeodon
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Injection
Used for
ZyprexaGeodon
Risk factors for serious side effects
ZyprexaGeodon
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • Low potassium
  • Low magnesium
Detailed Geodon (ziprasidone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZyprexaGeodon
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
ZyprexaGeodon
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
Weight
ZyprexaGeodon
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • It causes slightly less weight gain than similar medicines.
Upsides and benefits
ZyprexaGeodon
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
  • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
  • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
  • The Geodon (Ziprasidone) capsule is available as a generic.
  • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
  • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
Downsides and risks
ZyprexaGeodon
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
  • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
  • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
  • It causes slightly less weight gain than similar medicines.
  • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
Tips from our pharmacists for people taking the medication
ZyprexaGeodon
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
  • Take Geodon (Ziprasidone) twice a day, preferably with food.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
  • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
  • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it