Compare Zyprexa vs. Haldol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(olanzapine)

Haldol
(Haloperidol)

Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyprexa
Reviews for Zyprexa
41%
of people (All ages) say Zyprexa is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Reviews for Haldol
38%
+3% better vs. Zyprexa
42%
+9% better vs. Zyprexa
34%
-17% worse vs. Zyprexa
Have you used Haldol (Haloperidol)?
Worth itNot sureNot worth it
Side effects
ZyprexaHaldol
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Weight gain 5%
  • Personality disorder 4%
  • Constipation 6%
  • Dizziness 7%
  • Increased appetite 3%
  • Tremor 3%
  • Stomach problems 6%
  • Weakness 9%
More Zyprexa side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
How it works
ZyprexaHaldol
Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.
Type of medication
ZyprexaHaldol
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
ZyprexaHaldol
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
ZyprexaHaldol
Risk factors for serious side effects
ZyprexaHaldol
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Haldol (Haloperidol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZyprexaHaldol
No food related info.
  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
ZyprexaHaldol
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
Weight
ZyprexaHaldol
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
Upsides and benefits
ZyprexaHaldol
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Effective at relieving psychotic symptoms and agitation.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
Downsides and risks
ZyprexaHaldol
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • It's an older medicine and has a lot more side effects than newer antipsychotics.
  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
Tips from our pharmacists for people taking the medication
ZyprexaHaldol
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • For the first week, avoid activities like driving that require you to be alert.
  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
  • Don't use in elderly people who have dementia.
  • The oral liquid concentrate can be mixed with water or juice before taking it.
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Haldol (Haloperidol)?
Worth itNot sureNot worth it