Compare Zyprexa vs. Haldol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa (olanzapine)

Prescription only

Haldol (haloperidol)

Prescription only
Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

3.7/ 5 average rating with 68 reviewsforZyprexa
Helps control your thoughts, calm agitation, and stabilize your mood.

Haldol (haloperidol) is less likely to cause weight gain and sedation, but more likely to cause movement disorders compared to other antipsychotics.

3.1/ 5 average rating with 50 reviewsforHaldol
Upsides
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Haldol (haloperidol) is available in a cheap, generic version.
  • A monthly extended-release injection allows for more convenient dosing than a daily pill.
Downsides
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • Haldol (haloperidol) is an older medicine and has a lot more problematic side effects compared to newer antipsychotics.
  • You might need routine blood tests and regular check-ups to make sure the medicine is working for you.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Liquid
  • Injection
Price
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Reviews
68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle

Have you used Zyprexa (olanzapine)?

Leave a review
50 reviews so far
38%
saidit'sworth it
42%
saiditworked well
34%
saidit'sa big hassle

Have you used Haldol (haloperidol)?

Leave a review
Side effects
9possible side effects
  • Drowsiness
    48%
  • Weight gain
    28%
  • Increased appetite
    28%
  • Headache
    17%
  • Fatigue
    14%
  • Dizziness
    7%
  • Dry Mouth
    7%
  • Abdominal pain
    6%
  • Pain in extremity
    5%
See more detailed side effects
The Haldol (haloperidol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar, high cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Driving impairment
    • Drinking alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings