Compare Zyprexa vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(Olanzapine)

Invega
(Paliperidone)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyprexa
Reviews for Zyprexa (Olanzapine)
41%
of people (All ages) say Zyprexa (Olanzapine) is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it
Reviews for Invega (Paliperidone)
29%
12% vs. Zyprexa (Olanzapine)
32%
19% vs. Zyprexa (Olanzapine)
35%
+16% vs. Zyprexa (Olanzapine)
Have you used Invega (Paliperidone)?
Worth itNot sureNot worth it
Side effects
ZyprexaInvega
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 16%
  • Headache 11%
  • Fatigue 8%
  • Dizziness 7%
  • Constipation 5%
  • Abnormal gait 5%
  • Accidental injury 4%
More Zyprexa side effects »
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
How it works
ZyprexaInvega
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
ZyprexaInvega
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
ZyprexaInvega
  • Pill
  • Dissolving tablet
  • Injection
  • Extended release
  • Injection
Used for (click to learn more)
ZyprexaInvega
Risk factors for serious side effects
ZyprexaInvega
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZyprexaInvega
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
ZyprexaInvega
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
Weight
ZyprexaInvega
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain and low blood pressure.
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Upsides and benefits
ZyprexaInvega
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause heart or liver problems than some other antipsychotic medications.
Downsides and risks
ZyprexaInvega
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
  • Sometimes causes weight gain and low blood pressure.
  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Not a good choice for elderly people who have dementia.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
  • You might need routine blood tests to check how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
ZyprexaInvega
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Elderly people with dementia shouldn't take it.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • For the first week, avoid activities like driving that require you to be alert.
  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it
More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invega (Paliperidone)?
Worth itNot sureNot worth it