Compare Zyprexa vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(olanzapine)

Invega
(paliperidone)

Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyprexa
Reviews for Zyprexa
41%
of people (All ages) say Zyprexa is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Reviews for Invega
29%
+12% better vs. Zyprexa
32%
+19% better vs. Zyprexa
35%
-16% worse vs. Zyprexa
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it
Side effects
ZyprexaInvega
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Weakness 9%
  • Stomach problems 6%
More Zyprexa side effects »
  • Abnormally fast heart beat 5%
  • Drowsiness 2%
  • Dizziness 1%
  • Abdominal pain upper 2%
  • Dry mouth 2%
  • Heart block 1%
  • Fatigue 1%
More Invega side effects »
How it works
ZyprexaInvega
Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
ZyprexaInvega
Prescription onlyPrescription only
Available as
ZyprexaInvega
  • Pill
  • Dissolving tablet
  • Injection
  • Extended release
  • Injection
Used for
ZyprexaInvega
Risk factors for serious side effects
ZyprexaInvega
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Invega (paliperidone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZyprexaInvega
No food related info.
  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
ZyprexaInvega
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
Weight
ZyprexaInvega
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain and low blood pressure.
Upsides and benefits
ZyprexaInvega
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause heart or liver problems than some other antipsychotic medications.
Downsides and risks
ZyprexaInvega
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
  • Sometimes causes weight gain and low blood pressure.
  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Not a good choice for elderly people who have dementia.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
Tips from our pharmacists for people taking the medication
ZyprexaInvega
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • For the first week, avoid activities like driving that require you to be alert.
  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invega (paliperidone)?
Worth itNot sureNot worth it