Compare Zyprexa vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa (olanzapine)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

5.1/ 7 average rating with 68 reviewsforZyprexa
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Injection
  • Dissolving pill
Price
Lowest price near you
$12.05
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Lowest price near you
$568.43
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Reviews
68 
41%
think this treatment is worth it
51%
think this treatment works well
51%
think this treatment is a hassle

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Side effects
9possible side effects
  • Drowsiness
    48%
  • Weight gain
    28%
  • Increased appetite
    28%
  • Headache
    17%
  • Fatigue
    14%
  • Dizziness
    7%
  • Dry Mouth
    7%
  • Abdominal pain
    6%
  • Pain in extremity
    5%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Higher blood sugar, high cholesterol, and weight gain

    People with diabetes

    ...and 1 more risk factors

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Changes in blood pressure and fainting

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings