Compare Zyprexa vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coming soon.

Zyprexa
(Olanzapine)

Saphris
(Asenapine)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Coming soon.
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Reviews & ratings
Filter group. All currently selected
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5.09Zyprexa
Reviews for Zyprexa (Olanzapine)
41%
of people (All ages) say Zyprexa (Olanzapine) is worth it
51%
say it works well
51%
say it's a big hassle
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it

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Have you used Saphris (Asenapine)?
Worth itNot sureNot worth it
Side effects
ZyprexaSaphris
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 16%
  • Headache 11%
  • Fatigue 8%
  • Dizziness 7%
  • Constipation 5%
  • Abnormal gait 5%
  • Accidental injury 4%
More Zyprexa side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
ZyprexaSaphris
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
ZyprexaSaphris
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
ZyprexaSaphris
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
Used for (click to learn more)
ZyprexaSaphris
  • Bipolar I disorder
Risk factors for serious side effects
ZyprexaSaphris
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ZyprexaSaphris
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
ZyprexaSaphris
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness.
No sleep related info.
Weight
ZyprexaSaphris
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No weight related info.
Upsides and benefits
ZyprexaSaphris
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
Coming soon
Downsides and risks
ZyprexaSaphris
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Coming soon
Tips from our pharmacists for people taking the medication
ZyprexaSaphris
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Coming soon
Learn more
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (Olanzapine)?
Worth itNot sureNot worth it
More about SaphrisSide effectsReviews & ratingsFDA package insert
Have you used Saphris (Asenapine)?
Worth itNot sureNot worth it