Compare Zyprexa vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(Olanzapine)

Saphris
(Asenapine)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.098039215686274Zyprexa
Reviews for Zyprexa (Olanzapine)
45%
of people say Zyprexa (Olanzapine) is worth it
53%
say it works well
47%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ZyprexaSaphris
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
ZyprexaSaphris
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
ZyprexaSaphris
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
ZyprexaSaphris
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
Used for (click to learn more)
ZyprexaSaphris
  • Bipolar I disorder
Risk factors for serious side effects
ZyprexaSaphris
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Zyprexa (Olanzapine) risks & warnings »
          Coming soon.
          Pregnancy category
          ZyprexaSaphris
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Can cause dizziness and drowsiness.
          No specific sleep-related info.
          Weight
          • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific weight-related info.
          Upsides and benefits
          ZyprexaSaphris
          • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
          • Lowers relapse rates for schizophrenia and bipolar disorder.
          • Antipsychotic medicines are all about equally effective.
          • Less likely to cause heart problems than some antipsychotics.
          Coming soon.
          Downsides and risks
          ZyprexaSaphris
          • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • Might make you more sleepy than some antipsychotics.
          • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Coming soon.
          Tips from our pharmacists for people taking the medication
          ZyprexaSaphris
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness and drowsiness.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Coming soon.
          Learn more
          More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
          More about SaphrisSide effectsReviews & ratingsFDA package insert