Compare Zyprexa vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyprexa
(Olanzapine)

Seroquel
(Quetiapine)

Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.098039215686274Zyprexa
Reviews for Zyprexa (Olanzapine)
45%
of people say Zyprexa (Olanzapine) is worth it
53%
say it works well
47%
say it's a big hassle
Reviews for Seroquel (Quetiapine)
52%
+7% vs. Zyprexa (Olanzapine)
46%
7% vs. Zyprexa (Olanzapine)
28%
+19% vs. Zyprexa (Olanzapine)
Side effects
ZyprexaSeroquel
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
How it works
ZyprexaSeroquel
Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
ZyprexaSeroquel
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
ZyprexaSeroquel
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
ZyprexaSeroquel
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Zyprexa (Olanzapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)
Risk factors for serious side effects
ZyprexaSeroquel
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Zyprexa (Olanzapine) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Seroquel (Quetiapine) risks & warnings »
                  Pregnancy category
                  ZyprexaSeroquel
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • Can cause dizziness and drowsiness.
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  Weight
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  ZyprexaSeroquel
                  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
                  • Lowers relapse rates for schizophrenia and bipolar disorder.
                  • Less likely to cause heart problems than some antipsychotics.
                  • Antipsychotic medicines are all about equally effective.
                  • Effective at relieving psychotic symptoms and manic episodes.
                  • Fewer side effects than most antipsychotic medicines.
                  • Less likely to cause heart problems compared to some antipsychotics.
                  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Antipsychotic medicines are all about equally effective.
                  Downsides and risks
                  ZyprexaSeroquel
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • Might make you more sleepy than some antipsychotics.
                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • In studies, less effective for people over age 40 for schizophrenia.
                  • Sometimes causes weight gain, sleepiness, and low blood pressure.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  Tips from our pharmacists for people taking the medication
                  ZyprexaSeroquel
                  • Can cause dizziness and drowsiness.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  • Can cause dizziness, drowsiness, and low blood pressure.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  Learn more
                  More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
                  More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert