Compare Zyrtec D vs. Advil Cold And Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D (Cetirizine / Pseudoephedrine)

Prescription or OTC
Relieves congestion and allergy symptoms.

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

5.1/ 7 average rating with 927 reviewsforZyrtec D
Relieves sinus pain and congestion.

Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.

5.0/ 7 average rating with 1464 reviewsforAdvil Cold And Sinus
Upsides
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
Downsides
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
Used for
Dosage forms
  • Extended release
  • Pill
No pricing information available
No pricing information available
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Reviews
927 
75%
think this treatment is worth it
43%
think this treatment works well
9%
think this treatment is a hassle

Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?

Leave a review
1464 
75%
think this treatment is worth it
34%
think this treatment works well
6%
think this treatment is a hassle

Have you used Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)?

Leave a review
Side effects
The Zyrtec D (Cetirizine / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
The Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizure

    History of seizure

  • Harm to fetus

    Women of childbearing age

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Overdosage

    Current kidney disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Harm to fetus

    Women of childbearing age

  • High blood pressure

    History of high blood pressure

  • Lower kidney function

    Kidney disease

    ...and 4 more risk factors

  • Heart attack or stroke

    History of heart problems

    ...and 2 more risk factors

See more detailed risks and warnings