Compare Zyrtec D vs. Advil Cold And Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D
(cetirizine / pseudoephedrine)

Advil Cold And Sinus
(ibuprofen / pseudoephedrine)

Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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Prices and coupon for 60 (12 hour) tablets of cetirizine / pseudoephedrine
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Prices and coupon for 20 (200mg/30mg) tablets of ibuprofen / pseudoephedrine
Reviews & ratings
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5.09Zyrtec D
Reviews for Zyrtec D (cetirizine / pseudoephedrine)
75%
of people (All ages) say Zyrtec D (cetirizine / pseudoephedrine) is worth it
43%
say it works well
9%
say it's a big hassle
927 reviews
Have you used Zyrtec D (cetirizine / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Advil Cold And Sinus (ibuprofen / pseudoephedrine)
75%
Same vs. Zyrtec D (cetirizine / pseudoephedrine)
34%
-9% worse vs. Zyrtec D (cetirizine / pseudoephedrine)
6%
+3% better vs. Zyrtec D (cetirizine / pseudoephedrine)
1464 reviews
Have you used Advil Cold And Sinus (ibuprofen / pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
Zyrtec DAdvil Cold And Sinus

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »

We haven’t found good data for Advil Cold And Sinus side effects.

FDA side effect reports for Advil Cold And Sinus »
How it works
Zyrtec DAdvil Cold And Sinus
Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Zyrtec DAdvil Cold And Sinus
Prescription or OTC
Over-the-counter
Available as
Zyrtec DAdvil Cold And Sinus
  • Extended release
  • Pill
Used for
Zyrtec DAdvil Cold And Sinus
Risk factors for serious side effects
Zyrtec DAdvil Cold And Sinus
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec D (cetirizine / pseudoephedrine) risks & warnings »
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Women of childbearing age
    • History of high blood pressure
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
    Detailed Advil Cold And Sinus (ibuprofen / pseudoephedrine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Interactions
    Zyrtec DAdvil Cold And Sinus
    No interactions related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    Kidneys and liver
    Zyrtec DAdvil Cold And Sinus
    • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
    Pain
    Zyrtec DAdvil Cold And Sinus
    No pain related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    Sleep
    Zyrtec DAdvil Cold And Sinus
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    No sleep related info.
    Upsides and benefits
    Zyrtec DAdvil Cold And Sinus
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
    • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
    • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
    Downsides and risks
    Zyrtec DAdvil Cold And Sinus
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    Tips from our pharmacists for people taking the medication
    Zyrtec DAdvil Cold And Sinus
    • Starts working in 30 minutes.
    • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Starts working in 30 minutes.
    • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Take it after eating to avoid getting an upset stomach.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
    • Talk to your doctor if symptoms don't get better in 1 week.
    Learn more
    More about Zyrtec DSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zyrtec D (cetirizine / pseudoephedrine)?
    Worth itNot sureNot worth it
    More about Advil Cold And SinusSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Advil Cold And Sinus (ibuprofen / pseudoephedrine)?
    Worth itNot sureNot worth it