Compare Zyrtec D vs. Advil Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D
(cetirizine / pseudoephedrine)

Advil Congestion Relief
(ibuprofen / phenylephrine)

Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Zyrtec D
Reviews for Zyrtec D
75%
of people (All ages) say Zyrtec D is worth it
43%
say it works well
9%
say it's a big hassle
927 reviews
Have you used Zyrtec D (cetirizine / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Advil Congestion Relief
73%
+2% better vs. Zyrtec D
32%
+11% better vs. Zyrtec D
7%
-2% worse vs. Zyrtec D
1125 reviews
Have you used Advil Congestion Relief (ibuprofen / phenylephrine)?
Worth itNot sureNot worth it
Side effects
Zyrtec DAdvil Congestion Relief

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »
How it works
Zyrtec DAdvil Congestion Relief
Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Zyrtec DAdvil Congestion Relief
Prescription or OTCOver-the-counter
Available as
Zyrtec DAdvil Congestion Relief
  • Extended release
  • Pill
Used for
Zyrtec DAdvil Congestion Relief
Risk factors for serious side effects
Zyrtec DAdvil Congestion Relief
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Zyrtec D (cetirizine / pseudoephedrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
Detailed Advil Congestion Relief (ibuprofen / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
Zyrtec DAdvil Congestion Relief
No interactions related info.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
Kidneys and liver
Zyrtec DAdvil Congestion Relief
  • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Congestion Relief (Ibuprofen / Phenylephrine) for any amount of time.
Sleep
Zyrtec DAdvil Congestion Relief
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
No sleep related info.
Upsides and benefits
Zyrtec DAdvil Congestion Relief
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Zyrtec DAdvil Congestion Relief
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
Tips from our pharmacists for people taking the medication
Zyrtec DAdvil Congestion Relief
  • Starts working in 30 minutes.
  • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
  • Starts working in 30 minutes.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Zyrtec DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyrtec D (cetirizine / pseudoephedrine)?
Worth itNot sureNot worth it
More about Advil Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil Congestion Relief (ibuprofen / phenylephrine)?
Worth itNot sureNot worth it