Compare Zyrtec D vs. Allegra-D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D (Cetirizine / Pseudoephedrine)

Prescription or OTC
Relieves congestion and allergy symptoms.

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

5.1/ 7 average rating with 927 reviewsforZyrtec D
Treats allergy symptoms and congestion.

Allegra-D (fexofenadine / pseudoephedrine) is a combination allergy medicine that's useful if you have congestion and runny nose.

Upsides
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • Allegra-D (fexofenadine / pseudoephedrine) contains two medicines that work in different ways to help relieve multiple symptoms including nasal congestion and allergies.
  • Available without a prescription in the drugstore.
Downsides
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • You must show a photo ID to purchase this medicine from behind the pharmacy counter. There's a maximum limit on how much Allegra-D (fexofenadine / pseudoephedrine) you can buy at a time.
  • Allegra-D (fexofenadine / pseudoephedrine) can have more side effects (such as increased blood pressure and difficulty sleeping) than Allegra since it has pseudoephedrine in it.
  • If you have severe high blood pressure or heart disease you can't take this medicine. If you have kidney damage, you may not be able to take Allegra-D (fexofenadine / pseudoephedrine).
Used for
Dosage forms
  • Extended release
  • Pill
No pricing information available
No pricing information available
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Reviews
927 
75%
think this treatment is worth it
43%
think this treatment works well
9%
think this treatment is a hassle

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Side effects
The Zyrtec D (Cetirizine / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    13%
  • Trouble sleeping
    13%
  • Nausea
    7%
  • Dry Mouth
    3%
  • Indigestion
    3%
  • Throat irritation
    2%
  • Dizziness
    2%
  • Agitation
    2%
  • Back pain
    2%
  • Palpitations
    2%
See more detailed side effects
Risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizure

    History of seizure

  • Harm to fetus

    Women of childbearing age

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Overdosage

    Current kidney disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizure

    History of seizure

See more detailed risks and warnings