Compare Zyrtec D vs. Sudafed

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D
(Cetirizine / Pseudoephedrine)

Sudafed
(Pseudoephedrine)

Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.
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Reviews & ratings
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5.084233261339093Zyrtec D
Reviews for Zyrtec D (Cetirizine / Pseudoephedrine)
75%
of people (All ages) say Zyrtec D (Cetirizine / Pseudoephedrine) is worth it
43%
say it works well
9%
say it's a big hassle
926 reviews
Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Sudafed (Pseudoephedrine)
82%
+7% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
45%
+2% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
6%
+3% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
1732 reviews
Have you used Sudafed (Pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
Zyrtec DSudafed

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »
How it works
Zyrtec DSudafed
Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.
Type of medication
Zyrtec DSudafed
Antihistamine
2nd generation
DecongestantPrescription or OTC
DecongestantPrescription or OTC
Available as
Zyrtec DSudafed
  • Extended release
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
Zyrtec DSudafed
Risk factors for serious side effects
Zyrtec DSudafed
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec D (Cetirizine / Pseudoephedrine) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
    • History of seizures
    • Women of childbearing age
    Detailed Sudafed (Pseudoephedrine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Kidneys and liver
    Zyrtec DSudafed
    • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    No kidneys and liver related info.
    Sleep
    Zyrtec DSudafed
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    Upsides and benefits
    Zyrtec DSudafed
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
    • Clears nasal congestion better than other decongestants like phenylephrine.
    • Can be helpful in relieving congestion-related headaches and pressure in your ears.
    • Available in regular and extended release forms.
    Downsides and risks
    Zyrtec DSudafed
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
    • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
    • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
    Tips from our pharmacists for people taking the medication
    Zyrtec DSudafed
    • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Starts working in 30 minutes.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Talk to your doctor if your symptoms don't get better in 1 week.
    • Starts working in 30 minutes.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    Learn more
    More about Zyrtec DSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?
    Worth itNot sureNot worth it
    More about SudafedSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Sudafed (Pseudoephedrine)?
    Worth itNot sureNot worth it