Compare Zyrtec D vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec D
(Cetirizine / Pseudoephedrine)

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.084233261339093Zyrtec D
Reviews for Zyrtec D (Cetirizine / Pseudoephedrine)
75%
of people say Zyrtec D (Cetirizine / Pseudoephedrine) is worth it
43%
say it works well
9%
say it's a big hassle
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
1% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
31%
12% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
5%
+4% vs. Zyrtec D (Cetirizine / Pseudoephedrine)
Side effects
Zyrtec DTylenol Sinus

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »
How it works
Zyrtec DTylenol Sinus
Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Zyrtec DTylenol Sinus
Antihistamine
2nd generation
DecongestantPrescription or OTC
Pain reliever
APAP
DecongestantOver-the-counter
Available as
Zyrtec DTylenol Sinus
  • Extended release
  • Pill
Used for (click to learn more)
Zyrtec DTylenol Sinus
Risk factors for serious side effects
Zyrtec DTylenol Sinus
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec D (Cetirizine / Pseudoephedrine) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • History of high blood pressure
    • Taking MAO inhibitors
    • Women of childbearing age
    Detailed Tylenol Sinus (Acetaminophen / Phenylephrine) risks & warnings »
    Pregnancy category
    Zyrtec DTylenol Sinus
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • People age 65 and older have a higher risk of troublesome side effects from taking antihistamine medications like Zyrtec D (Cetirizine / Pseudoephedrine). Watch out for changes in vision, severe dry mouth, trouble urinating, or constipation. Also, feelings of drowsiness may leave you "unsteady" on your feet. This can make you more likely to fall causing broken bones or other serious injuries. Talk with your doctor before using Zyrtec D (Cetirizine / Pseudoephedrine) and stop using it if you have side effects.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Zyrtec DTylenol Sinus
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
    Downsides and risks
    Zyrtec DTylenol Sinus
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    Zyrtec DTylenol Sinus
    • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Starts working in 30 minutes.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Follow age-specific dosing instructions on how much to take.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Starts working in 30 minutes.
    Learn more
    More about Zyrtec DSide effectsReviews & ratingsAlternativesFDA package insert
    More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert